Lymphoma is a type of cancer that begins in lymphocytes. Lymphocytes are cells in the immune system. Hodgkin’s and non-Hodgkin’s lymphoma are the two main kinds of lymphoma.

“Non-Hodgkin’s lymphoma can be divided into two types, T-cell and B-cell. There is a rare type of cancer called NK-cell lymphoma.”

Among people with non-Hodgkin’s lymphoma, about 85 percent have B-cell lymphoma, according to the American Cancer Society (ACS).

The specific stage and type of B-cell lymphomas are what determines treatment.

There are many different types of B-cell lymphoma, including slow-growing and fast-growing.

B-cell subtype Characteristics
Diffuse large B-cell lymphoma (DLBCL) This is the most common type of non-Hodgkin’s lymphoma. It’s an aggressive but treatable cancer that can involve lymph nodes and other organs.
Follicular lymphoma This is the second most common type of non-Hodgkin’s lymphoma. It’s typically slow-growing and usually starts in the lymph nodes.
Mantle cell lymphoma Generally, it involves lymph nodes, bone marrow, spleen, and the gastrointestinal system. It is usually slow-growing, but it’s hard to treat.
Chronic lymphocytic leukemia (CLL)/Small lymphocytic lymphoma (SLL) This type is indolent and typically affects the blood and bone marrow (CLL), or lymph nodes and spleen (SLL).
Primary central nervous system lymphoma This type usually starts in the brain or spinal cord. It’s associated with immune problems caused by AIDS or anti-rejection medications used following organ transplantation.
Splenic marginal zone B-cell lymphoma This is a rare, slow-growing type that begins in the spleen, blood, and bone marrow.
Extranodal marginal zone B-cell lymphoma (MALT) This type usually involves the stomach. It can also occur in the lungs, skin, thyroid, salivary gland, or eye.
Nodal marginal zone B-cell lymphoma This is a rare, slow-growing type found mainly in the lymph nodes.
Burkitt lymphoma This is a fast-growing type that is more common in children.
Hairy cell leukemia This is a slow-growing type that affects the spleen, lymph nodes, and blood.
Lymphoplasmacytic lymphoma (Waldenstrom macroglobulinemia) This is a rare, slow-growing lymphoma of the bone marrow, spleen, and lymph nodes.
Primary effusion lymphoma This is a rare, aggressive type that begins in the eyeball and tends to occur in people who have a weakened immune system, possibly due to AIDS or anti-rejection medication following organ or tissue transplants.


“Cancer is staged to spread from the original site. The most advanced stage of non-Hodgkin’s lymphoma is from 1 to 4.”

B-cell lymphoma symptoms can vary depending on the type and how advanced it is. These are some of the symptoms.

  • There are swollen lysies in your neck, armpits, or groin.
  • There is abdominal pain or swelling.
  • There is chest pain.
  • coughing
  • breathing difficulties
  • Night sweats and a high temperature.
  • unexplained weight loss
  • fatigue

“Some types of lymphoma don’t need treatment. Your doctor may recommend that you wait. You will follow up every few months to make sure the cancer isn’t getting worse. This can continue for a long time.”

If there are signs of disease progression, treatment can begin. Treatments for B-cell lymphoma can change over time.


Using high powered energy beams, radiation therapy is used to kill cancer cells and shrink tumors. It requires lying very still on a table while the beams are directed to a precise point on your body.

Radiation therapy may be all you need for slow-growing, locally-sourced lymphoma.

There are side effects that can include fatigue and skin irritation.


Chemotherapy is a systemic treatment that can be given orally or intravenously. Some aggressive B-cell lymphomas can be cured with chemotherapy, especially in early stage diseases.

DLBCL is a fast-growing type that can be treated with a chemotherapy regimen called CHOP (cyclophosphamide, doxorubicin, vincristine, and prednisone). When given along with the monoclonal antibody rituximab (Rituxan), it’s called R-CHOP. It’s usually given in cycles several weeks apart. It’s hard on the heart, so it’s not an option if you have preexisting heart problems.

Nausea, fatigue, and hair loss are some of the side effects of chemotherapy.


Your immune system is able to fight cancer. The immune system can identify and destroy B-cells that are affected by Rituximab. The drug will cause your body to produce new healthy B-cells. It is less likely that cancer will recur.

Radioimmunotherapy medications are made of monoclonal antibodies that carry radioactive isotopes. The drug helps the immune system to fight cancer.

Immune therapy can cause low white blood cell counts, fatigue, and infections.

Stem cell transplant

A stem cell transplant involves replacing your bone marrow with marrow from a healthy donor. First, you’ll need high dose chemotherapy or radiation to suppress your immune system, destroy cancer cells, and make room for the new marrow. To be eligible, you must be healthy enough to withstand this treatment.

Side effects can include infections, anemia, and rejection of the new bone marrow.

Targeted therapy

Targeted therapy may be used to treat B-cell lymphomas. This type of medication treatment is designed to target changes in the cells that help them grow. Sometimes they can work for a patient who has not received any benefit from standard treatment.

You are more vulnerable to infections because of the weakened immune system. Some treatments for lymphoma can cause problems.

B-cell lymphomas can grow and spread.

“Some B-cell lymphomas can be cured. Treatment can slow the progression of others. If there is no sign of cancer after your primary treatment, you are in complete remission. You will need to follow up for several years to make sure you don’t repeat.”

Is B-cell lymphoma fatal?

“The survival rates for B-cell lymphoma have increased each decade as a result of treatment advances. Most people with non-Hodgkin’s lymphoma are still alive five years after the disease was found.”

The chances of survival are higher when the disease is caught early.

What is the survival rate for B-cell lymphoma?

The overall 5-year relative survival rate for “Non-Hodgkin’s lymphoma is not a cancer.”is 73 percent, per the ACS.

This is different depending on the type of B-cell lymphoma and stage at diagnosis. Your age and health are other considerations.

Your doctor can give you a personal prediction based on your health profile.

Is high grade B-cell lymphoma curable?

There are other types of B-cell lymphoma, but the types that are most commonly are called high grade or fast-growing.

Sometimes, low grade B-cell lymphoma can change into high grade over time. Some people may have both high and low grade lymphoma at the same time.

“This type of disease is not life threatening. Depending on the type of lymphoma and the person’s health, treatment can vary.”

Is B-cell lymphoproliferative disorder cancer?

B-cell lysproliferative disorders are a type of disease where the white blood cells are being produced at an uncontrollable rate.

These disorders are related.

  • B-cell chronic lymphocytic leukemia is a type of leukemia.
  • B-cell prolymphocytic leukemia is a leukemia.
  • “Non-Hodgkin’s lymphoma is not a cancer.”
  • hairy cell leukemia
  • There is a type of cancer called splenic lymphoma.