If you have a certain type of blood cancer, your doctor might discuss Bosulif as a treatment option for you.

Bosulif is a prescription medication that’s used to treat a form of chronic myelogenous leukemia in certain adults.

Bosutinib is the active ingredient in the drug. An active ingredient is what makes a drug work.

Rounding out the drug class is called boisulif. A drug class is a group of drugs that work in the same way. You can take a tablet called boisulif.

This article describes the usual dosages of Bosulif, as well as its strengths and how to take the drug. To learn more about Bosulif, see this in-depth article.

Note: This article covers Bosulif’s usual dosages, which are provided by the drug’s manufacturer. But when using Bosulif, always take the dosage that your doctor prescribes.

Below you’ll find common dosage information for Bosulif. For more details, you can refer to the Bosulif package insert.

What is Bosulif’s form?

You can take a tablet called boisulif.

Bosulif strengths (100 mg, 400 mg, 500 mg)

The three strengths of boisulif are 100, 400 and 500.

What are the usual dosages of Bosulif?

Factors that affect your dosage of Bosulif include your condition, your overall health, and whether you have tried other kinds of treatment before.

In some cases, your doctor may increase your dose based on how your body responds to treatment.

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

Dosing for newly diagnosed Philadelphia chromosome-positive (Ph+) chronic myeloid leukemia (CML)

The daily dose of the boasulif is 400, for newly diagnosed CML that has not yet been treated.

Dosing for Ph+ CML that has been previously treated

500 of the boasulif is taken per day for CML. If you had tried another treatment for CML, you would have had side effects from it.

Is Bosulif used long term?

It is usually taken as a long-term treatment. If you and your doctor agree that it is safe and effective for you, you will probably take it for a long time.

Dosage adjustments

Your Bosulif dosage may need to be adjusted if you have certain conditions, such as a liver, kidney, or blood disorder.

You may also need a dosage adjustment if you experience serious side effects. These might include raised liver enzyme levels, severe diarrhea, or blood disorders such as low white blood cell levels or low levels of platelets (cells that help with blood clotting). For more information about Bosulif’s side effects, see this article.

“If you don’t get the results you want, your doctor may increase your dosage by 100 percent. In some cases, your dosage may be increased to a maximum of 600mg taken once per day.”

Your doctor will give you more information if you need a different dose of Bosulif.

The amount of Bosulif you are prescribed may be affected by a number of factors. These include:

  • The type and severity of the condition you are treating.
  • Your age.
  • You may have other conditions that are not listed here.
  • You experience serious side effects.
  • You may be taking other drugs.

You can take a tablet called boisulif. You’ll take Bosulif once per day with food. Try to take your dose around the same time every day. This helps keep a steady level of the medication in your body. You shouldn’t crush, split or chew Bosulif tablets.

If you have trouble swallowing pills, see this article for tips on how to take tablets.

Only a few specialty pharmacies offer boisulif. Your doctor can give you more information about where you can get your prescription filled.

For information on Bosulif expiration, storage, and disposal, see this article.

If you forget to take your dose, take it as soon as you remember. If it has been more than 12 hours since you were supposed to take it, you should take your next dose at its regular time.

You should not take two doses of the same drug at the same time. This could increase your risk of side effects.

If you need help remembering to take your dose of Bosulif on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more than your doctor prescribes. Taking more than this can cause serious side effects.

What to do in case you take too much Bosulif

Call your doctor right away if you think you’ve taken too much Bosulif. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The dosages provided by the drug manufacturer are described in the sections above. If your doctor recommends it, they will prescribe the correct amount of the drug.

Remember, you should not change your dosage of Bosulif without your doctor’s recommendation. Only take Bosulif exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Some questions you may want to ask your doctor.

  • Is a lower dose of Bosulif still effective?
  • Does my dosage need to change if I take other drugs?
  • Will my dosage be adjusted if I have side effects with the drug?


Will I need to adjust my dosage if I have a bad reaction to the drug?



It is possible. When you begin treatment, you may experience a side effect called diarrhea. This is a side effect for most people.

If you have a disease, your doctor may recommend avoiding certain foods. Taking an over-the-counter treatment such as loperamide may be one of the suggestions.

If you have a severe case of scurvy, you should call your doctor immediately. They may want you to stop taking the drug until your scurvy goes away. They will likely restart your treatment at a lower dose. If you are still having severe scurvy, they may lower your dose again or you may have to stop taking the drug.

If you are concerned about your risk of having a bad reaction to the drug, talk to your doctor.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.