Eliquis (apixaban) is a prescription drug used in adults to prevent and treat certain kinds of blood clots, including pulmonary embolism and deep vein thrombosis. Like other drugs, Eliquis may have interactions.

One substance can cause another substance to have a different effect than expected. Alcohol, another drug, or a supplement can affect how a drug works in your body. If you have certain health conditions, interactions can occur.

Keep reading to learn about the possible interactions of Eliquis. And for more information about Eliquis, including details about its uses, see this article.

If you have a health condition, you could be at increased risk of harm if you take Eliquis. Your doctor may not prescribe Eliquis in these cases. These are not good for you. Thecontraindications of Eliquis are listed below.

If you have active bleeding. You shouldn’t take Eliquis if you have any bleeding occurring, including bleeding inside your body. An example is gastrointestinal bleeding (bleeding in the stomach or intestines). Eliquis increases your risk of bleeding. Using Eliquis could worsen bleeding that’s already happening.

If you’ve had an allergic reaction. Your doctor likely won’t prescribe Eliquis if you’ve had an allergic reaction to the drug or any of its ingredients. You can ask your doctor about other treatments that may be better options for you.

If any of the factors above apply to you, talk with your doctor before you start taking Eliquis. Eliquis can be determined by your doctor.

Alcohol and Eliquis are not known to interact with each other.

Eliquis and alcohol make it harder for your blood to clot. It is possible that drinking alcohol while taking Eliquis could increase your risk of bleeding.

If you drink alcohol, talk to your doctor about how much you can safely consume during Eliquis treatment.

Inform your doctor and pharmacist about any prescription drugs you take before you start taking Eliquis. Sharing this information with them may help prevent future interactions.

If you have questions about drug interactions, talk to your doctor or pharmacist.

The drugs that may interact with Eliquis are listed in the chart. The chart does not include all drugs that may interact with Eliquis. The “Drug interactions explained” section gives more information about some of the interactions.

Drug group or drug name Drug examples Interaction result with Eliquis
nonsteroidal anti-inflammatory drugs (NSAIDs) aspirin
• ibuprofen (Advil)
naproxen (Aleve, Naprosyn)
meloxicam (Mobic)
• celecoxib (Celebrex)
can increase the risk of side effects from Eliquis
anticoagulants • rivaroxaban (Xarelto)
warfarin (Jantoven)
heparin
• dabigatran (Pradaxa)
can increase the risk of side effects from Eliquis
certain antiepileptic drugs carbamazepine (Tegretol)
phenytoin (Dilantin)
can make Eliquis less effective than usual
certain antifungal drugs ketoconazole
• itraconazole (Sporanox, Tolsura)
can increase the risk of side effects from Eliquis
any treatment that includes ritonavir • ritonavir (Norvir)
• ritonavir and lopinavir (Kaletra)
• ritonavir and nirmatrelvir (Paxlovid)
can increase the risk of side effects from Eliquis
methyltestosterone (Methitest) can increase the effect of Eliquis
rifampin (Rifadin) can make Eliquis less effective than usual

There are certain drug interactions that can occur with Eliquis.

Interaction with nonsteroidal anti-inflammatory drugs

NSAIDs are used to relieve pain. Eliquis can interact with nonsteroidal anti-inflammatory drugs (NSAIDs) as described in the table below.

What could happen Examples of NSAIDs What you can do
can increase the risk of bleeding, including severe bleeding aspirin
• ibuprofen (Advil)
• celecoxib (Celebrex)
naproxen (Aleve)
meloxicam (Mobic)
Ask your doctor if it’s safe for you to take an NSAID with Eliquis. They may recommend that you avoid taking these drugs together.

Interaction with methyltestosterone

Methyltestosterone (Methitest) is a drug used to treat low testosterone and certain kinds of breast cancer in females.* Eliquis can interact with methyltestosterone as described in the table below.

* In this article, we use the term “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

What could happen What you can do
can increase the effect of Eliquis and increase your risk of bleeding If you take methyltestosterone and Eliquis together, tell your doctor. They’ll closely monitor you for signs of bleeding.

Interaction with other anticoagulants

Eliquis belongs to a group of drugs called anticoagulants, also known as blood thinners. It can interact with other anticoagulant medications as described in the table below.

What could happen Examples of other anticoagulants What you can do
can increase the effect of Eliquis and increase your risk of bleeding • rivaroxaban (Xarelto)
warfarin (Jantoven)
heparin
• dabigatran (Pradaxa)
Before you start taking Eliquis, tell your doctor it you’re already taking an anticoagulant. Due to this risk, doctors will not prescribe Eliquis and another anticoagulant together.

Eliquis may have other interactions. They could happen with supplements or food. See below for more.

Does Eliquis interact with supplements?

Before you start taking Eliquis, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.

If you have questions about interactions, talk to your doctor or pharmacist.

Eliquis interactions with herbs

Eliquis can interact with the herb St. John’s wort. Specifically, St. John’s wort can make Eliquis less effective. Due to this risk, doctors will recommend that you do not take St. John’s wort and Eliquis together.

“If you want to keep taking St. John’s wort, you should talk to your doctor. They may suggest a different medication for you.”

Eliquis and vitamins

There are currently no reports of Eliquis interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.

It is still important to check with your doctor or pharmacist before taking any of these products.

Does Eliquis interact with food?

Eliquis can interact with grapefruit. Specifically, grapefruit can increase the risk of side effects from Eliquis, particularly bleeding.

It is recommended that you avoid consuming any products with grapefruit in them. If you consume grapefruit frequently, your doctor may lower your Eliquis dose.

Does Eliquis interact with vaccines?

Eliquis is not known to interact with vaccines.

Tell your doctor or pharmacist what you take if you need a vaccine. They can tell you if it is safe to get the vaccine.

Does Eliquis interact with lab tests?

Eliquis is not known to interact with lab tests.

If you have any concerns about your lab tests interacting with your medications, talk to your doctor.

Does Eliquis interact with cannabis or CBD?

There are currently no reports of Eliquis interacting with cannabis (commonly referred to as marijuana) or cannabis products such as cannabidiol (CBD). But as with any drug or supplement, talk with your doctor before using cannabis with Eliquis.

Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.

There is a risk of interactions with Eliquis for certain medical conditions. Discuss your health history with your doctor before taking Eliquis. They will determine if Eliquis is right for you.

Other factors that might interact with Eliquis include:

  • Active bleeding. You should not take Eliquis if you have any bleeding occurring. For more information, see the “When to avoid Eliquis” section above.
  • Antiphospholipid syndrome (APS). Eliquis can increase the risk of blood clots in people with APS. If you have this syndrome, your doctor will likely not prescribe Eliquis for you. They’ll discuss treatments that are safer than Eliquis.
  • Kidney problems. Your body depends on your kidneys to rid itself of Eliquis after you take a dose. If you have kidney problems, such as chronic kidney disease, Eliquis levels may build up in your body. This can increase your risk of side effects. Depending on your kidney health and other factors, your doctor may prescribe a lower Eliquis dose.
  • Severe liver problems. It’s not known whether Eliquis is safe or effective in people with severe liver problems, such as severe cirrhosis. If you have a liver problem, tell your doctor before you start taking Eliquis. They can discuss with you whether Eliquis is a good treatment option based on your liver health.
  • Pregnancy. It’s not known if it’s safe to take Eliquis while pregnant. If you’re pregnant or planning to become pregnant, talk with your doctor about possible treatment options for your condition.
  • Breastfeeding. It’s not known whether it’s safe to breastfeed while taking Eliquis. If you’re breastfeeding or planning to do so, talk with your doctor. They can discuss with you treatment options that may be safe while breastfeeding your child.
  • Allergic reaction. If you’ve had an allergic reaction to Eliquis or any of its ingredients, your doctor will likely not prescribe Eliquis. You can ask them about other treatments that may be better choices for you.

Answers to frequently asked questions about Eliquis can be found.

Does Tylenol (acetaminophen) interact with Eliquis?

No, Eliquis and Tylenol are not known to interact with each other.

Nonsteroidal anti-inflammatory drugs (NSAIDs) can interact with Eliquis, increasing your risk of bleeding. NSAIDs are a kind of pain-relieving medication. Examples include ibuprofen (Advil) and naproxen (Aleve). Tylenol is not an NSAID.

NSAID and tylenol are used to treat headaches and muscle pains. It is believed that Tylenol is safe to take with Eliquis.

Is it safe to take amoxicillin and Eliquis together?

Yes, amoxicillin and Eliquis are safe to take together.

Amoxicillin is an antibiotic used to treat certain infections. Amoxicillin itself doesn’t interact with Eliquis.

But amoxicillin is sometimes prescribed with other antibiotics that can interact with Eliquis. For example, it may be prescribed with the drugs clarithromycin and lansoprazole (Prevacid) to treat H. pylori bacterial infections. Clarithromycin may interact with Eliquis.

If you are prescribed it alone, Eliquis is a good choice. If you need more than one antibiotic, you should let your doctor know you are taking Eliquis. They may not prescribe an antibiotic that interacts with Eliquis. They may temporarily lower your Eliquis dose until you stop taking the antibiotic.

Can I take doxycycline with Eliquis?

Yes, you may take doxycycline (Vibramycin, Doryx) with Eliquis. There’s no known interaction between doxycycline and Eliquis.

Doxycycline is an antibiotic. Eliquis does not interact with other antibiotics. Ask your doctor or pharmacist if you have questions about Eliquis and antibiotics.

Is it safe to have testosterone injections while taking Eliquis?

It should be safe. There is no known interaction between Eliquis and testosterone.

Testosterone injections are used to treat low testosterone and certain kinds of breast cancer in females.* If your doctor prescribes testosterone injections for you, they’ll also likely have you continue taking Eliquis.

Eliquis can interact with the drug, which comes in forms that you take. Eliquis is not known to have an interaction with testosterone injections.

Ask your doctor or pharmacist if you have questions about testosterone and Eliquis.

* In this article, we use the term “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

Is it safe to take a zinc supplement while I’m taking Eliquis?

Zinc is not thought to have any relationship with Eliquis.

Before taking zinc, be sure to talk with your doctor or pharmacist. They can check if zinc interacts with other drugs or medical conditions.

Taking certain steps can help you avoid getting into arguments with Eliquis. Talk to your doctor and pharmacist before treatment begins. Things to discuss with them.

It’s also important to read Eliquis’ label and other paperwork that comes with the drug. You may see colored stickers on the label that describe interactions. And the paperwork (sometimes called the prescribing information) may have other details about interactions. If you need help understanding this information, talk with your doctor or pharmacist.

Taking Eliquis exactly as prescribed can help prevent interactions.

If you still have questions, you should talk to your doctor.

You may want to ask your doctor some questions.

  • Will my Eliquis dose affect my risk of interactions?
  • Is Eliquis still safe if I have a health condition?
  • “Is there any medication I can take to treat a headaches that don’t interact with Eliquis?”
  • What should I do if I start taking a new medication while Eliquis is in effect?

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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.