If you have headaches, your doctor may recommend Emgality. Emgality is a drug. It is used in adults.

If you’d like more information about these conditions, see the “What’s Emgality used for?” section below.

The active drug in Emgality is galcanezumab, which is a biologic medication. Biologic are made from parts of living organisms. Emgality is not available in a biosimilar form. (Biosimilars are like generic drugs. But unlike generics, which are made for nonbiologic drugs, biosimilars are made for biologic drugs.) Instead, galcanezumab comes only as the brand-name drug Emgality.

You will take emgality as an injection. It can be a prefilled pen or a prefilled syringe. You can give injections to yourself if your doctor shows you how.

Read on to learn about the possible side effects of Emgality.

Mild or serious side effects may occur with Emgality. Some of the more common side effects of Emgality are described in the lists below. All possible side effects are not included in these lists.

The doctor or pharmacist can tell you more about the side effects of Emgality. They can suggest ways to reduce the effects.

Mild side effects

Here’s a short list of some of the mild side effects that Emgality can cause. To learn about other mild side effects, talk with your doctor or pharmacist or read Emgality’s patient information.

Mild side effects of Emgality can include symptoms at the site where the drug is injected.

Many drugs can have mild side effects that go away in a few days or weeks. If they become intolerable, talk to your doctor or pharmacist.

The “Side effect focus” section gives more information about the symptoms at the site of Emgality injections.

Serious side effects

Serious side effects from Emgality are not common. If you have serious side effects from Emgality, you should call your doctor. If you think you have a medical emergency, you should call the emergency number.

Serious side effects of Emgality can include allergic reaction, which is explained below in “Side effect focus.”

Side effect focus

Some of the side effects of Emgality can be found here.

Painful, red, or itchy skin after injection

You may have It is a pain., It is itchy., redness, or deepening of skin color at your injection site after giving yourself a dose of Emgality. This side effect was common in clinical studies of the drug.

What can help?

There are a few suggestions that might help.

  • “Don’t rub the skin around the injection site. Doing so can make your symptoms worse.”
  • Apply a cold compress to your skin to help reduce the It is a pain. and swelling.
  • Use over-the-counter (OTC) medications, such as ibuprofen (Advil) or acetaminophen (Tylenol), to help lessen the It is a pain..
  • Use OTC antihistamines, such as diphenhydramine (Benadryl), or hydrocortisone cream to help relieve the itching.
  • “You should place the drug at different sites. Don’t inject Emgality into the same area of skin every time.”

Talk with your doctor if you have concerns about any It is a pain., redness, deepening of skin color, or swelling you experience after using Emgality.

Allergic reaction

Some people have an allergy to Emgality. It can happen immediately or it can happen several days after the drug is taken.

A mild allergic reaction can include some symptoms.

  • There is a rash.
  • It is itchy.
  • flushing (warmth, swelling, redness, or deepening of skin color)

A more severe allergic reaction is not uncommon. A severe allergic reaction can cause swelling under your skin, which can be seen in your eyes, lips, hands, and feet. They can include swelling of your mouth, throat, and tongue, which can cause trouble breathing.

If you have an allergic reaction to Emgality, call your doctor. If you think you have a medical emergency, call the emergency number.

Find answers to questions about Emgality.

How does Emgality compare with Aimovig?

Both Emgality and Aimovig are injections used to help prevent migraine headaches in adults. Emgality can also be prescribed to treat episodic cluster headaches. But Aimovig isn’t used for this purpose.

There are different active drugs in Emgality and Aimovig. Aimovig and Emgality both contain galcanezumab.

If you have questions about which drug is better for you, talk to your doctor.

How does Emgality work?

Emgality works by blocking the action of a protein in your body called calcitonin gene-related peptide (CGRP). CGRP can play a role in causing migraine and cluster headaches.

Emgality helps prevent and treat cluster headaches by stopping CGRP from working.

If you want to know more about Emgality, you should talk to your doctor.

Will Emgality cure my headaches?

“No, Emgality won’t cure your headaches. There is no cure for migraines at the moment. As long as you keep taking it, Emgality can help prevent migraines.”

If you have questions about using Emgality, talk to your doctor.

There are many factors that affect the cost of prescription drugs. What your insurance plan covers is one of the factors.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. You can also visit the Emgality manufacturer’s website to see if they have any support options.

Emgality is prescribed for adults.

  • Preventing migraine headaches. With migraine, you usually have severe headaches along with other symptoms. These other symptoms may include nausea and sensitivity to sound or light. Migraine episodes can last for several hours to several days.
  • Treating episodic cluster headaches. With cluster headaches, you have cycles of sudden, It is a pain.ful headaches followed by periods with no headache. With episodic cluster headaches, your headache cycles happen regularly for up to 1 year. Then, your headache-free period lasts for up to 1 year before your headache cycle starts again.

Emgality works by blocking the activity of a protein in your body called calcitonin gene-related peptide. This protein plays a role in both migraine and cluster headaches.

“Your doctor will explain how to take it. They will explain how much to take and how often. Follow your doctor’s instructions.”

Below are some commonly used dosages, but always take the dosage your doctor prescribes.

Taking Emgality

Emgality is a solution inside prefilled pens and needles. Your doctor can tell you what form is best for you.

You’ll inject Emgality under your skin. But before you administer a dose, your doctor or healthcare professional will show you how to do so.

The locations where erotic stimulation should be injected are:

  • Your stomach.
  • Your thigh.
  • The back of your arm.
  • Your buttocks.

You can give yourself injections after your first dose. You could have a family member give you the injections.


The amount of Emgality you take depends on the condition you are treating.

The first two injections of Emgality are usually used to prevent headaches. You will probably only give yourself one injection per month after that.

You will likely use three injections for every dose if you use Emgality to treat headaches. When your cycle of cluster headaches begins, your first dose is usually given. You will take three injections a month until your cycle ends.

Questions about taking Emgality

Some people ask questions about taking Emgality.

  • What if I miss a dose of Emgality? If you miss a dose of Emgality, inject your missed dose as soon as you remember. Your next dose should be taken 1 month from the date you took the missed dose. For example, if you took your missed dose on the 5th of the month, you should reschedule your upcoming doses to the 5th of each month. Because Emgality is typically taken once per month, your future doses should be rescheduled for that same date. If you have questions about a missed dose, talk with your doctor.
  • Will I need to use Emgality long term? As long as Emgality keeps working for you, your doctor will likely recommend that you continue taking it long term.
  • Should I take Emgality with food? You can take Emgality with or without food.
  • How long does Emgality take to work? It may take several weeks for you to notice your condition improving.

It is important to talk with your doctor about your health and any medical conditions you may have if you are considering taking Emgality. You should consider the following before taking it.


Using medications, vaccines, foods, or other things alongside a certain drug can affect how the drug works. These effects are called interactions.

“Because of the way Emgality works in your body, it isn’t known to interact with other drugs, supplements, or foods.”

Before taking Emgality, be sure to tell your doctor about all your medication. You should describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions these items may cause.

Other warnings

If you have a medical condition that affects your health, ecstasy may not be right for you. Before you take Emgality, talk to your doctor about your health history. An allergic reaction is one of the factors to consider.

Allergic reaction. If you’ve had an allergic reaction to Emgality or any of its ingredients, you shouldn’t take this drug. Ask your doctor about which other medications are better options for you.

Use with alcohol

It is not known if drinking alcohol while taking Emgality causes problems.

It is important to know if alcohol causes your headaches. If it does, you will want to avoid drinking alcohol while taking Emgality.

If you have questions about the amount of alcohol that is safe to drink while taking this drug, talk to your doctor.

Pregnancy and breastfeeding

There is not enough information about the effects of Emgality on pregnant women. It is not known if the drug can cause harm to an unborn baby or human breast milk.

If you have questions about the risks of using Emgality while you are pregnant or breastfeeding, talk to your doctor.

“Don’t take more than your doctor prescribes. Side effects can be serious if you use more than this.”

What to do in case you take too much Emgality

Call your doctor if you think you’ve taken too much Emgality. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or you can use its online resource. But if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

If you want to learn more about whether Emgality is the right treatment for your condition, talk to your doctor or pharmacist.

You may have questions about how to treat headaches. There are a few resources with information.

You may want to ask your doctor about it. Here are a few questions to help you get started.

  • Should I use other drugs to treat or prevent headaches if I take Emgality?
  • What is the difference between Emgality and other medications that help prevent headaches?
  • Will Emgality cure my headaches?
  • I have cluster headaches and should I keep using Emgality?

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Is it possible to use Emgality to treat migraines after they start?



Migraine symptoms are supposed to be treated once they start. Emgality is approved for preventing headaches.

Emgality works by blocking the action of a protein called calcitonin gene-related peptide (CGRP). CGRP can play a role in causing migraine headaches. By stopping CGRP from working, Emgality helps prevent migraine headaches. But the drug isn’t likely to relieve symptoms once you already have a migraine headache.

Talk to your doctor about the treatment of migraines. They can suggest the best treatment for you based on your health. They may recommend over-the-counter drugs. They may suggest some non-medication treatments, such as applying an ice pack or staying quiet until your symptoms improve.

You can also refer to this article for ways to handle migraine symptoms that have already started.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.