If you have multiple sclerosis (MS), your doctor may prescribe Gilenya for you. It’s used in certain people with MS.

MS is a condition that affects communication between your brain and spinal cord, and the rest of your body.

Gilenya can be used in adults and children with multiplesclerosis.

It’s also used to treat a condition called clinically isolated syndrome (CIS). This is often a first sign of MS, but doesn’t always lead to it.

For more information on the specific uses of Gilenya, see the “Is Gilenya used for MS?” section below.

Gilenya ingredients and form

The active drug ingredient in Gilenya is fingolimod. It’s only available as a brand-name medication. There are no generic forms of Gilenya.

You can take Gilenya by mouth. You will only need to take Gilenya once a day.

“Learn more about Gilenya’s side effects.”

Gilenya may cause some long-term side effects, like mild or serious side effects. The side effects described below are more common. All possible side effects are not included in these lists.

Side effects of a drug can depend on other factors.

  • Your age.
  • You have other health conditions.
  • You are taking other medications.

The doctor or the pharmacy can tell you more about the side effects of Gilenya. They can suggest ways to reduce them.

Mild side effects

Here’s a list of some of the mild side effects that Gilenya can cause. To learn about other mild side effects, talk with your doctor or pharmacist, or read Gilenya’s medication guide.

There are some mild side effects of Gilenya that have been reported.

Many drugs can have mild side effects that go away in a few days or weeks. If they become intolerable, talk to your doctor or pharmacist.

The side effect focus section gives more information on this side effect.

Serious side effects

Gilenya can have serious side effects, but they are not common. If you have serious side effects from Gilenya, you should call your doctor. If you think you have a medical emergency, you should call the emergency number.

There have been serious side effects of Gilenya.

The side effect focus section gives more information on this side effect.
† This wasn’t reported in studies of Gilenya but has been reported in people who took the drug once it became available. See the “What should be considered before taking Gilenya?” section below for details.

Side effect focus

Some of the side effects of Gilenya may be discussed.

Diarrhea

You may experience diarrhea while you take Gilenya. Diarrhea is one of the more common side effects of the drug.

Diarrhea from Gilenya is usually temporary or manageable. In studies, no one had to stop taking the drug due to diarrhea.

What can help?

The following tips can help with managing scurvy.

  • Stay hydrated. Dehydration (low fluid level in your body) from diarrhea can become serious, especially in children and older adults. Drink plenty of fluids when you have diarrhea, such as water or sports drinks with electrolytes.
  • Eat bland foods. Eating certain easy-to-digest foods can help. Consider following the BRAT diet, which consists of bananas, rice, applesauce, and toast. This diet may help ease short-term diarrhea.

If you have a bad case of scurvy while you are taking Gilenya, talk to your doctor. They may be able to suggest ways to decrease the side effect.

Eye-related side effects

It is possible that Gilenya may cause eye-related side effects.

Specifically, Gilenya can cause macular edema, which is a fluid buildup in part of your eye called the retina. People who have this side effect usually have symptoms within the first 3 to 4 months after starting Gilenya treatment.

“Some people don’t have any symptoms of the eye disease. Other people may experience symptoms.”

What can help?

Your doctor will recommend an eye exam before you start taking Gilenya. They will recommend another eye exam after you start treatment. Before and after starting Gilenya, you have to take exams to compare your vision.

If you have diabetes or a history of uveitis (swelling in your eye), be sure to tell your doctor. If you have these conditions, there is a higher risk of developing macular edema while taking Gilenya. Your doctor may suggest a different treatment option for you.

If you have any symptoms of Maceo-Malformation while taking Gilenya, you should immediately tell your doctor.

If your macular edema is severe, your doctor may recommend treating it. They may also recommend that you stop taking Gilenya. In studies, most cases of macular edema either improved or went away completely after this medication was stopped.

Progressive multifocal leukoencephalopathy (PML)

Progressive multifocal leukoencephalopathy (PML) is a very rare but serious infection that’s been reported with Gilenya use. Although PML didn’t occur in studies, there have been reports of this side effect happening. In these reports, most cases of PML occurred in people with a weakened immune system. And they usually happened in people taking Gilenya for longer than 2 years.

PML is an infection that affects the brain and can cause disability or even death.

It is very rare, but you should report the symptoms of PML to your doctor. Symptoms may get worse over time.

What can help?

Your doctor will keep an eye on you for symptoms of PML. If you develop symptoms, see a doctor. Your doctor will likely recommend that you stop taking Gilenya.

Allergic reaction

Allergic reaction has been reported with Gilenya use, but it’s not known how often it occurs.

A mild allergic reaction can include some symptoms.

  • It is itchy.
  • There is a skin rash.
  • flushing (temporary warmth, redness, or deepening of skin color)

A more severe allergic reaction is not uncommon. There are symptoms of a severe allergic reaction.

  • urticaria (hives)
  • angioedema (swelling under your skin), typically in your eyelids, lips, hands, or feet
  • It can cause trouble breathing if you have swelling of your tongue, mouth, or throat.

If you have an allergic reaction to Gilenya, call your doctor. If you think you have a medical emergency, call the emergency number.

If you have multiple sclerosis (MS), your doctor may recommend Gilenya.

It’s used to treat certain types of MS and a condition called clinically isolated syndrome (CIS). Gilenya is used in adults and children ages 10 years and older for:

  • CIS. This is often the first stage of MS. But CIS doesn’t always lead to MS.
  • Relapsing-remitting multiple sclerosis (RRMS). With RRMS, your MS symptoms relapse (get worse), then remit (improve), in a cycle.
  • Active secondary-progressive multiple sclerosis (SPMS). With SPMS, your MS symptoms continue to get worse.

MS affects the covering of your nerves that connect your brain and spinal cord to the rest of your body. With MS, your immune system attacks this covering. This decreases your brain’s ability to communicate with the rest of your body.

You may have the disease.

It’s not known exactly how Gilenya works to treat MS. It’s possible that Gilenya treats MS by decreasing the amount of white blood cells in your brain and spinal cord. (Your white blood cells make up part of your immune system.)

Some questions about Gilenya are answered below.

Is Gilenya used to treat breast cancer?

No, Gilenya isn’t approved to treat breast cancer. It’s only approved to treat multiple sclerosis (MS) in certain people.

Taking Gilenya may increase your risk for certain types of cancer, including skin cancer and lymphoma.

A study is underway to see if Gilenya could be used for nerve pain from chemotherapy that’s used to treat breast cancer. In this study, Gilenya is being used to help with the nerve pain, not to treat the breast cancer itself.

If you have breast cancer, you should talk to your doctor about your treatment plan.

Will I have weight loss or weight gain while I’m taking Gilenya?

Taking Gilenya should not affect your weight. Weight loss and weight gain weren’t reported as side effects in studies of the drug.

Still, changes in weight are common in people with MS, which Gilenya is used to treat. Symptoms of the disease, such as depression, fatigue (lack of energy), or trouble walking may result in weight gain. And an MS flare-up that is being treated with steroids may also result in weight gain. (Steroids can cause you to gain weight.)

Some people with the disease may lose weight. This can be caused by decreased muscle activity. Depression with Multiplesclerosis can cause weight loss.

If you lose or gain weight while taking Gilenya, talk to your doctor. They will be able to help figure out what is causing your weight to change.

What’s the difference between Gilenya and Ocrevus?

Both Gilenya and Ocrevus are medications used to treat the following relapsing forms of MS:

Both drugs are also used to treat clinically isolated syndrome (CIS). This is often the first stage of MS, but doesn’t always lead to MS.

Ocrevus is also approved to treat a form of MS called primary progressive MS (PPMS).

Another big difference between the two medications is the way you take them. Gilenya is a capsule that you’ll take by mouth once daily. Ocrevus is a liquid solution that’s injected into a vein in your arm. You only need to get one dose of Ocrevus twice each year.

There are different active drugs in these medications. They may cause you to have different side effects.

If you have questions about which treatment option is best for you, talk to your doctor or pharmacist. They will be able to help you decide which medication is best for you.

* To learn more about CIS, RRMS, and SPMS, see the “Is Gilenya used for MS?” section above.

How does Gilenya work?

“Gilenya’s mechanism of action is not known.”

It’s thought that Gilenya works by reducing the number of white blood cells in your brain and spinal cord. Your white blood cells make up part of your immune system. And in people with MS, the immune system attacks the covering of brain and spinal cord nerves.

If you have questions about how Gilenya can help you with the disease, you should talk to your doctor or pharmacist.

Will stopping Gilenya lead to withdrawal symptoms?

No, stopping Gilenya won’t cause withdrawal symptoms. But stopping the medication may cause your MS symptoms to come back. Withdrawal refers to symptoms that occur when you stop taking a medication that your body is dependent on.

Stopping Gilenya may also lead to severe worsening of MS in some people. This may occur within 12 weeks of stopping the drug, but it can happen later. Many people whose MS got worse after stopping Gilenya did not have the same level of ability as before or during treatment.

If you need to stop taking Gilenya, you should speak with your doctor. Tell them if your symptoms get worse after you stop Gilenya. Your doctor will suggest ways to treat the symptoms.

Is it safe to suddenly stop taking Gilenya?

Unless your doctor recommends it, you should not stop taking Gilenya.

Stopping Gilenya can cause MS symptoms to come back. And they may become worse than they were before Gilenya treatment. It’s also possible that stopping Gilenya may lead to severe worsening of MS. Many people whose MS got worse after stopping Gilenya did not have the same level of ability as before or during treatment.

If you think you need to stop taking this drug, you should talk to your doctor. They may switch you to a different medication to reduce the risk of your symptoms getting worse.

Your doctor will explain how you should take Gilenya. They’ll also explain how much to take and how often. Be sure to follow your doctor’s instructions. Below are commonly used dosages, but always take the dosage your doctor prescribes.

Taking Gilenya

You can take Gilenya by mouth with water.

You should take a dose each day. Gilenya should not be taken on a daily basis.

Dosage

Usually, Gilenya only needs to be taken once daily. Your dose will depend on Your age. and weight.

When you take your first dose of Gilenya, your doctor will monitor you, either in their office or at a hospital. This is because Gilenya may cause your heart rate to decrease to unsafe levels. And if that happens, you’ll be in your doctor’s office or a hospital, where you can be treated right away. Usually, people who have changes in heart rate or blood pressure experience these changes within 6 hours of their first dose.

Questions about taking Gilenya

Some questions about Gilenya are below.

  • What if I miss a dose of Gilenya? You should try not to miss a dose of Gilenya. If you miss one or more doses, your doctor may check your heart after you take a dose, the same as when you first start treatment. (This means you may have to go to your doctor’s office or a hospital for another 6 hours when you take your next dose.) If you miss a dose, call your doctor right away. They’ll be able to tell you what to do about your next dose.
  • Will I need to use Gilenya long term? If Gilenya works for you, your doctor may recommend that you take it long term. But discuss your specific treatment plan with them before starting Gilenya.
  • Can Gilenya be chewed, crushed, or split? Gilenya is a capsule that’s swallowed with water. The manufacturers of Gilenya don’t give any recommendations about chewing, crushing, or splitting Gilenya capsules. If you’re having trouble swallowing the capsules, talk with your doctor or pharmacist. They may be able to recommend ways to make your medication easier to swallow.
  • Should I take Gilenya with food? You can take your dose of Gilenya with or without food.
  • How long does Gilenya take to work? Gilenya starts to work as soon as you take your first dose. But it can take weeks or even months before you notice your symptoms getting better. Talk with your doctor about when you can expect your symptoms to start improving.

Questions for your doctor

You may have questions about Gilenya. Discuss your concerns with your doctor.

Here are a few tips that might help you.

  • Before your appointment, write down questions such as:
    • How will Gilenya affect my life?
  • Bring someone with you to your appointment to make you feel more comfortable.
  • “If you don’t understand something, ask your doctor to explain it.”

“Your doctor and other healthcare professionals are available to help you. They want you to get the best care possible. Don’t be afraid to ask questions or give feedback on your treatment”

Before you start taking Gilenya, you should tell your doctor about your health. This includes all of your medical conditions and any medications you are taking.

Other medical conditions or drugs can interact with Gilenya.

These and other considerations are described in detail.

Interactions

Taking medications, vaccines, foods, and other things with a certain drug can affect how the drug works. These effects are called interactions.

Before taking Gilenya, you should tell your doctor about all your medication. You should also describe any vitamins, herbs, or supplements you use. Your doctor or pharmacist can tell you about any interactions that may occur.

Interactions with drugs or supplements

Gilenya can interact with a lot of drugs. These drugs are used.

Some drugs that may interact with Gilenya are not on this list. Your doctor or pharmacist can tell you more about the interactions that may occur with Gilenya.

Other interactions

Gilenya can interact with certain vaccines.

You should not get live vaccines while taking Gilenya. You should not have them for at least 2 months.

Live vaccines contain weakened forms of live germs. Gilenya weakens the activity of your immune system. So getting a live vaccine while taking the drug may cause the infection the vaccine is meant to protect you from.

If you take Gilenya, you may not get the non-live vaccines you need. The vaccines are meant to protect you from live germs.

Your doctor will discuss your vaccine needs with you before Gilenya. They may recommend getting the vaccines before you start taking Gilenya.

Warnings

If you have a medical condition that affects your health, Gilenya may not be right for you. Before you take Gilenya, talk to your doctor about your health history. The factors to consider are listed below.

  • Current infections. Gilenya weakens the activity of your immune system, decreasing your body’s ability to fight infections. If you have any infections, your doctor will treat them before you start Gilenya.
  • Allergic reaction. If you’ve had an allergic reaction to Gilenya or any of its ingredients, you should not take Gilenya. Ask your doctor what other medications are better options for you.
  • Diabetes. If you have diabetes, you may have an increased risk for an eye problem called macular edema. Your doctor may monitor you more often than usual during treatment with Gilenya to watch for macular edema.
  • Uveitis (swelling in your eye). If you’ve had uveitis, you may have an increased risk for an eye problem called macular edema. Your doctor may monitor you more often than usual during treatment with Gilenya to watch for macular edema.
  • Liver problems. Gilenya may cause liver problems or changes in liver function tests. Talk with your doctor if you’ve ever had liver problems, as Gilenya may make them worse.
  • Heart problems. Gilenya can cause a sThe heart rate is low. or a condition called heart block. If you have a heart problem, Gilenya can make it worse. Examples of these heart problems include recent heart attack, unstable angina, stroke, heart failure, repeated fainting episodes, or a heart rhythm problem. If you have certain heart conditions, your doctor may recommend a different medication instead of Gilenya. In some cases, you may still be able to take Gilenya, but you’ll need monitored by your doctor more often than usual during treatment.
  • Recent vaccination. If you’ve recently gotten a vaccine, or you’re planning to get one, tell your doctor before you start Gilenya. They may suggest you wait before you begin Gilenya treatment.
  • Breathing problems, such as asthma. It’s possible that Gilenya may decrease the amount of air that you can breathe out of your lungs. If you have breathing problems, this decrease may make it more difficult for you to breathe. Your doctor may check your breathing during treatment with Gilenya.
  • High blood pressure. Gilenya can cause increased blood pressure. Tell your doctor if you already have high blood pressure, as Gilenya can make it worse.
  • Tumefactive multiple sclerosis (MS). Tumefactive MS can occur with Gilenya treatment. This is a rare type of MS that involves one or more masses in the brain. Be sure to talk with your doctor if you have a relapse (flare-up) of your MS symptoms during or after Gilenya treatment. Your doctor may recommend imaging tests to check for signs of tumefactive MS. This condition is more likely to occur if you’ve started or stopped Gilenya treatment recently, or if you have a severe relapse. Your doctor can tell you more about this.
  • Skin cancer. Gilenya may increase your risk for skin cancer. If you’ve ever had or you have skin cancer, tell your doctor before starting Gilenya.

Gilenya and alcohol

There are no known interactions between alcohol and Gilenya. It is possible that drinking alcohol while taking Gilenya increases your risk for side effects.

For example, Gilenya can cause liver problems, and so can alcohol. So, drinking alcohol if you’re taking Gilenya may increase your risk for liver problems.

If you are taking Gilenya, you should talk to your doctor about the amount of alcohol you should be drinking.

Pregnancy and breastfeeding

If you are planning to become pregnant, tell your doctor before starting Gilenya.

Gilenya and pregnancy

If you are pregnant, you should not take Gilenya. Birth control is recommended by your doctor for at least 2 months after you stop taking Gilenya. This is how long it can last.

There is a registry for pregnant people. A pregnancy registry is a collection of information about pregnant people. This information is used to help doctors and patients learn about the safety of drugs used during pregnancy.

You can learn more and sign up for the registry on this website or by calling 877-598-7237.

Gilenya and breastfeeding

It is not known if Gilenya is present in breast milk or if it is safe to breast feed a child while taking Gilenya.

If you are taking Gilenya, you should talk to your doctor about how to feed your child.

Both Gilenya and Tecfidera are used to treat certain forms of relapsing multiple sclerosis (MS).

You can take these medications by mouth. Gilenya capsule only needs to be taken once daily, while Tecfidera needs to be taken twice daily.

The medications have different active drugs that can cause different side effects.

If you’d like to learn more about how Gilenya and Tecfidera are similar and different, see this article. And be sure to discuss with your doctor which drug is right for you.

There are many factors that affect the cost of prescription drugs. What your insurance plan covers is one of the factors.

If you have questions about how to pay for your prescription, talk with your doctor or pharmacist. You can also visit the Gilenya manufacturer’s website to see if they have support options.

Do not take more Gilenya than your doctor tells you to. Side effects can be serious if you use more than this.

Symptoms of overdose

There are symptoms of an overdose.

What to do in case you take too much Gilenya

Call your doctor if you think you’ve taken too much Gilenya. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use its online resource. However, if you have severe symptoms, immediately call 911 (or your local emergency number) or go to the nearest emergency room.

If you have multiple sclerosis (MS), your doctor may prescribe Gilenya for you. It’s used in certain people with MS.

If you have questions about Gilenya, you should talk to your doctor. They will be able to discuss any concerns you have about this medication. They can help you decide if Gilenya is a good option for you.

Some questions that you may want to ask your doctor.

  • How can I prevent or treat the side effects of Gilenya?
  • Can I get the vaccine while I take Gilenya?
  • “What other treatment options are available if I can’t afford Gilenya?”
  • Is Gilenya a safe treatment option for my MS, even though I have other medical conditions?

For more information about MS and its treatment options, see this article. To learn about natural options for treating MS, you can read this article.

If you’d like to stay up to date on information about MS, including its treatment options, sign up for Healthline’s MS newsletter. You can also find advice and stories from others with your condition in the Bezzy MS community.

Q:

Will taking Gilenya cause sun sensitivity?

Anonymous

A:

Some drugs cause photosensitivity reactions, such as There is a skin rash.es or blisters, after you’re exposed to sunlight. But Gilenya isn’t one of them.

But taking Gilenya may increase your risk for certain types of skin cancer, such as melanoma.

Being safe in the sun is a good idea. It is important if you have a higher risk for skin cancer. Sun exposure tips include:

  • You should see a dermatologist to make sure your skin is good.
  • Tell your doctor right away if you notice any skin changes or unusual moles.
  • You should wear clothes that protect you from the sun.
  • Wear sunscreen any time you’re outdoors. Be sure to:
    • Wear a broad-spectrum, water-resistant sunscreen with an SPF of 30 or higher. This is recommended by The American Academy of Dermatology.
    • After swimming or sweating, apply sunscreen every 2 hours.

If you have questions about your risk for developing skin cancer, talk to your doctor.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.