If you have schizophrenia, your doctor might suggest Invega Trinza as a treatment option for you.

Invega Trinza is a medication that is used to treat schizophrenia. It can be used in people who have had good results with another drug called Invega.

You will receive the same medication, but you will get less of it. Invega Trinza and Invega Sustenna are given every 3 months.

The active ingredient in Invega Trinza is paliperidone palmitate. An active ingredient is what makes a drug work. A group of drugs called atypical antipsychotics are what it is.

Invega Trinza is given as an injection into a muscle. You’ll receive doses at your doctor’s office or another healthcare facility every 3 months.

There are other forms of Invega, including a tablet you take by mouth. This article only gives dosage information for Invega Trinza, including strengths and how to take the drug. This article does not cover all the forms of Invega. To learn more about Invega, see this in-depth article.

Note: This chart highlights the basics of Invega Trinza’s dosage. Be sure to read on for more detail. And please keep in mind that this article covers Invega Trinza’s standard dosage schedule, which the drug’s manufacturer provides. But your doctor will give you the dosage that is right for you at your appointment.

Invega Trinza form Invega Trinza strengths
Extended-release injectable suspension 273 milligrams (mg) per 0.88 milliliter (mL) solution
410 is 1 liter.
547 IU/ 1.7 mL.
819 IU/2.63 mL.

The manufacturer has provided information about the typical dosage of Invega Trinza.

What are the forms of Invega Trinza?

Invega Trinza comes as a suspension (a type of liquid mixture) that a doctor or another healthcare professional will administer as an injection into a muscle.

What strengths does Invega Trinza come in?

Invega Trinza has some strengths.

  • A small amount of medicine per 0.88 liters.
  • 410 is 1 liter.
  • 547 IU/ 1.7 mL.
  • 819 IU/2.63 mL.

What are the usual dosages of Invega Trinza?

Your doctor will usually start you on a dosage based on the Invega Sustenna you are taking. They may change your dose over time. They will prescribe the smallest dose that will provide the desired effect.

“You will receive Invega Trinza at your doctor’s office or another healthcare facility. A doctor or healthcare professional will inject a drug into your arm or buttocks.”

The information below describes commonly used or recommended dosages.

If you’ve been taking the same monthly dose of Invega Sustenna for at least 4 months, your starting dose of Invega Trinza will be based on that dose. You will receive the same medication, but you will get less of it. Invega Trinza and Invega Sustenna are given every 3 months.

Typically, your dose will be converted as follows.

Invega Sustenna last dose Invega Trinza first dose
78 mg 273 mg
117 mg 410 mg
156 mg 546 mg
234 mg 819 mg

“You can get Invega Trinza from your doctor on the day you would have gotten Invega Sustenna. You can receive your dose within a window of 7 days if you can’t go in on that day.”

You will have appointments every 3 months to get your injections.

Is Invega Trinza used long term?

Invega Trinza is a long-term treatment. If you and your doctor determine that Invega Trinza is safe and effective for you, you will likely use it for a long time.

Dosage adjustments

If you have kidney problems, you may need a lower dose of Invega Trinza. But in some cases, your doctor may not prescribe this drug, depending on how severe your kidney problems are.

If you need help remembering your Invega Trinza injection appointments, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Let your doctor know if you need to miss an appointment. They may need to adjust your dose. It is possible to receive your injection within 2 weeks after your scheduled injection day.

If you missed a dose, your doctor will determine if you can continue with the same dose or if you need to switch to Invega Trinza.

If you have questions about what your dose will be after missing an appointment, talk to your doctor.

The doctor may have a number of factors to consider when writing the Invega Trinza prescription. These include:

  • The severity of the condition you are treating.
  • Your age.
  • Invega Sustenna was your previous drug of choice.
  • You can have other conditions if you have what is called a “Dosage adjustments”.

“You will receive your injection at your doctor’s office or another healthcare facility. A doctor or healthcare professional will inject a drug into your arm or buttocks.”

“It is a good idea to plan for a ride home from your appointment if you don’t know how the Invega Trinza injection will affect you.”

There are serious side effects of using more than the prescribed amount of Invega Trinza. An overdose of Invega Trinza is unlikely because a doctor or another healthcare professional will give you the correct dose.

Symptoms of overdose

There are symptoms caused by an overdose.

What to do in case you take too much Invega Trinza

Call your doctor right away if you think you’ve taken/used too much Invega Trinza. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The dosages provided by the drug manufacturer are described in the sections above. If your doctor recommends Invega Trinza, they will prescribe the correct amount.

If you have questions about your current dose, talk to your doctor. Some questions you may want to ask are listed here.

  • Do I have to switch to Invega if my dose changes?
  • Is a lower dose of Invega Trinza going to make me less prone to have side effects?
  • Will my Invega Trinza dosage change if I start taking a new medication?
  • How should I prepare for my injections?


Will I take a different dose of Invega Trinza if I also take other medications?



It depends. You could take other medications with Invega Trinza. It is important to talk to your doctor about how your medication is working for you.

Some medications interact with Invega Trinza. For example, a medication called carbamazepine, and an over-the-counter herbal supplement called St. John’s wort both interact with Invega Trinza. It’s more likely that your doctor will advise you to avoid these interactions instead of changing your Invega Trinza dosage.

If you need to adjust your dosage often because of a medical condition, your doctor may prescribe paliperidone (the active drug in Invega Trinza) that you can take by mouth. (Invega Trinza is given as an injection into a muscle.)

Talk to your doctor if you have questions.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.