If you have an immunodeficiency related to certain infections, inflammatory diseases, or autoimmune disorders, you may have heard about an infusion treatment called intravenous immunoglobulin, or IVIG.
This therapy is primarily designed for situations where you may not have enough antibodies. An IVIG may also be used if your condition doesn’t respond to immunosuppressing medications.
IVIG is used for several medical conditions, but this treatment also has its own side effects and risks to consider. Read on to learn about the benefits and potential drawbacks of IVIG, and what it’s like to have an IVIG infusion.
IVIG is a therapy used to treat a variety of inflammatory and immune-mediated diseases. It is made from your immune system making antibodies.
The immunoglobulins in IVIG infusions are derived from thousands of healthy blood plasma donations. These infusions are also purified, making the chances of contracting any blood-borne diseases from donors very low.
Perhaps one of the greatest benefits of IVIG is that, unlike immunosuppressants, these infusions don’t increase your risk of infection.
“Your immune system can’t produce enough anti-infection antibodies when you have an IgA deficiency. This can make you more vulnerable to infections.”
Your doctor may also recommend an IVIG infusion
- systemic lupus
- “Sjgren’s syndrome is a genetic condition.”
- ITP is a disease of the thrombocytopenia.
- The disease is called Kawasaki.
- dermatomyositis is a disease.
- Polymyositis is a disease.
- primary immunodeficiency disease (PIDD)
- vasculitis is a disease.
- Idiopathic arthritis is a type of juvenile arthritis.
If you’re currently being treated for certain cancers, such as multiple myeloma, lymphoma, or chronic lymphocytic leukemia (CLL), your doctor may also recommend IVIG infusion to help counter the effects of your cancer treatments and
Can you have an IVIG infusion if you’re pregnant or nursing?
IVIG infusions are considered safe if you’re pregnant or nursing.
Depending on availability, IVIG may be provided at:
- An hospital.
- “A doctor’s office.”
- An outpatient center.
- In a hospital.
IVIG is given via a drip infusion through a vein in your arm. It takes about 3 hours to complete each infusion.
Are IVIG infusions painful?
While the infusion process itself isn’t painful, you may experience pain and discomfort when the needle is inserted into the vein in your arm. Talk with your doctor if you have a history of needle discomfort.
How many infusions will you need?
The number of sessions you need depends on what you’re being treated for. A one-time infusion may be needed for treating Kawasaki’s disease, but most other conditions require an average of one to five infusions per month.
When determining the dosage, your doctor will consider both your body weight and the condition being treated. In most cases, IVIG doses consist of 2 g/kg each session for 2 to 5 consecutive days.
How long does it take before you see results and how long do they last?
When undergoing IVIG treatment, it’s important to be patient, as it may take several weeks to see the full effects. If IVIG infusions work for your condition, the positive effects may last up to a few months at a time.
Talk to your doctor about vaccinations during IVIG treatment
During IVIG treatment, you may not be able to take vaccines because your immune system won’t fully respond to vaccinations as it should. Talk with your doctor about your current vaccination schedule.
It’s estimated that
However, most people who take IVIG do well with these infusions, and may only experience mild side effects, such as:
- The skin is irritated at the site of the injection.
- There are headaches.
- There is a process of flushing.
- There is a high degree of fever.
- “It’s cold.”
- The muscles are sore.
If you have a doctor that recommends taking over-the-counter pain medications, you should take them.
What are the risks of getting bloodborne infections from IVIG infusions?
The risk of getting bloodborne infections from blood donors used to create IVIG infusions is considered extremely low. This is because of the purification process that donated blood plasma goes through, which helps destroy infectious organisms, such as bacteria and viruses.
Additionally, IVIG donations are kept sealed in sterilized packages once the purification process is complete. This further helps the prevention of infectious disease transmission.
Rare but serious side effects
A rare, but serious side effect of IVIG therapy is a type of non-infection-related brain inflammation called aseptic meningitis. To help minimize the risk of developing meningitis, your doctor may recommend that you:
- Stay hydrated during and after treatment.
- Take steroids or anti-Inflammatory drugs.
- diphenhydramine is a drug.
Other risk factors to consider include:
- The heart failure is getting worse.
- Increased blood pressure.
- Increased risk of blood clot.
- high blood sugar.
- Severe allergic reactions.
- Hemolyticemia is a disease.
- There are problems with the kidneys or the liver.
The risk of severe side effects may also be greater in older adults.
Call your doctor right away if you or a loved one experience any of the following symptoms after receiving an IVIG infusion:
- breathing difficulties
- Severe, worsening rash.
- high There is a high degree of fever.
- severe There are headaches. with neck stiffness
- Nausea and vomiting.
- The chest is tight.
IVIG infusions may not be appropriate for everyone, due to side effects, comorbidities, or a lack of efficacy.
It is important to talk with your doctor about the risks and benefits of IVIG, as well as possible alternatives. Alternative treatments may include things.
- subcutaneous immunoglobulin (SCIG), which consists of immunoglobulin administered underneath your skin instead of intravenously
- immunosuppressant medications, such as steroids, biologics, and Janus kinase (JAK) inhibitors, to help stop your immune system from attacking itself
to helpsuppress your immune system and fight infections
IVIG gives your immune system the antibodies it needs to fight infections. IVIG can help suppress immune system attacks on healthy cells.
IVIG infusions have a risk of side effects that you should discuss with your doctor. Let your doctor know if you experience any adverse effects after you receive an IVIG.
IVIG infusions may work well in some cases, but there are other alternatives to consider.