If you have rheumatoid arthritis (RA) or certain rare genetic (inherited) conditions, your doctor might suggest Kineret as a treatment option for you.

The medication keeret is used to treat.

  • Some adults have active RA, which means the condition is causing symptoms.
  • NOMID is a disease that can be found in adults and children.
  • Adults and children have a deficiency ofDIRA.

Anakinra is the active ingredient in Kineret. An active ingredient is what makes a drug work. An interleukin-1 receptor antagonist is a type of drug.

The liquid solution in the prefilled syringes is called keeret. It’s given as an injection under your skin. Your doctor will show you how to give yourself Kineret injections at home.

This article describes the dosages of Kineret, its strength, and how to take it. To learn more about the drug, see this in-depth article or the Kineret prescribing information.

Note: This chart highlights the basics of Kineret’s dosage. Be sure to read on for more detail. And please keep in mind that this article covers Kineret’s standard dosage schedule, which is provided by the drug’s manufacturer. But always follow the dosing instructions your doctor prescribes.

Condition Kineret treats Recommended starting dose Recommended maximum dose
rheumatoid arthritis 100 milligrams per day (100 mg/day) 100 mg/day
NOMID 1 to 2 mg/kilogram* body weight (kg) per day 8 mg/kg per day
DIRA 1 to 2 mg/kg per day 8 mg/kg per day

The weight of 2.2 pounds is the number of one kilogram.

Below is information about Kineret’s dosage for treating rheumatoid arthritis (RA) and certain rare genetic (inherited) conditions.

What is Kineret’s form?

The liquid solution in the prefilled syringes is called keeret.

What strength does Kineret come in?

100 mol gal (mg) per 0.67 mol gal of solution is the strength of ketret.

What are the usual dosages of Kineret?

Depending on the condition you are treated for, your doctor may start you on a low dose. They will adjust your dose over time to reach the right amount for you. They will prescribe the smallest dose that will provide the desired effect.

The information below describes dosages that are commonly used or recommended. But be sure to take the Kineret dose your doctor prescribes. They’ll determine the best dosage to fit your needs.

Dosage for active rheumatoid arthritis (RA)

The recommended Kineret dose is 100mg injected once per day. The condition is active.

Dosage for neonatal-onset multisystem inflammatory disease (NOMID)

The recommended starting dose of Kineret is 1 to 2 grams per kilo of body weight. The weight is 2.2 pounds.

Your doctor may increase your dose to the maximum over time.

You can either get your dose once daily or split it into two. If you split your dose into two injections, you will need a new keraet syringe.

Dosage for deficiency of interleukin-1 receptor antagonist (DIRA)

The recommended starting dose is 1 to 2 grams of body weight per day. The weight is about 2.2 lbs.

Your doctor may increase your dose up to the maximum amount you can take.

You can either get your dose once daily or split it into two. If you split your dose into two injections, you will need a new keraet syringe.

What’s the dosage of Kineret for children?

In children, keeret is used to treat NOMID and deficiency ofDIRA.

The same amount of keeret is used in children and adults. The “What are the usual dosages of Kineret?” section is where you can learn more.

Is Kineret used long term?

It is usually used as a long-term treatment. If you and your doctor determine that Kineret is safe and effective for you, you will likely use it for a long time.

Dosage adjustments

Your doctor may prescribe a lower Kineret dose if you have severe kidney problems, such as end-stage kidney disease. To learn more, talk with your doctor.

The liquid solution in the prefilled syringes is called keeret. It’s given as an injection under your skin, and your doctor will show you how to give yourself Kineret injections at home.

If your child is prescribed Kineret, the drug manufacturer provides a video explaining how to give your child the injections.

For information on Kineret expiration, storage, and disposal, see this article.

Accessible drug containers and labels

“If you can’t read the prescription label on your medication, you should tell your doctor or pharmacist. Some pharmacies may provide medication labels.”

  • Large print or use of blind.
  • You can use a code on a phone to change the text to sound.

“If your current pharmacy doesn’t offer accessibility features, your doctor or pharmacist may be able to recommend a new pharmacy.”

Below are answers to some questions.

How long does it take Kineret to work?

Kineret begins working as soon as you inject a dose. But it can take 4 weeks or longer before you notice a change in your symptoms. In studies of Kineret, some people’s symptoms weren’t eased for several months after starting treatment.

If you have questions about when you can expect to see results, talk to your doctor. They can tell you more about how they check if Kineret works for you.

Is Kineret used for systemic juvenile idiopathic arthritis (SJIA)? If so, what’s the dosage?

“SJIA isn’t treated with Kineret. The drug may be used to treat SJIA. Off-label use is when a drug is prescribed to treat a condition that isn’t FDA-approved to treat.”

Some studies have shown that Kineret may be safe to use for treating SJIA. Kineret is approved to treat SJIA in the European Union. But it’s not approved for this use in the United States.

If you want to learn more about the off-label uses of Kineret, you should talk to your doctor.

If you miss a dose, call your doctor. They can tell you when to give your injection.

If you need help remembering to inject your dose of Kineret on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

The amount of keeret you are prescribed may be affected by a number of factors. These include:

  • The type and severity of the condition you are treating.
  • Your body weight is in kilograms.
  • You may have other conditions that are not listed here.

Do not use more than your doctor prescribes. Side effects can be severe if you use more than this.

What to do in case you use too much Kineret

Call your doctor right away if you think you’ve used too much Kineret. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The dosages provided by the drug manufacturer are described in the sections above. If your doctor recommends it, they will prescribe the correct amount of Kineret.

Remember, you should not change your dosage of Kineret without your doctor’s recommendation. Use Kineret exactly as prescribed. If you have questions or concerns about your dosage, talk with your doctor.

Some questions you may want to ask your doctor.

  • Does my Kineret dosage need to change if I am also taking other medications?
  • Is there a lower dosage I can try if I have side effects after taking Kineret?
  • What is the highest recommended dose of Kineret for treating my condition?

If you have rheumatoid arthritis (RA), you can sign up for Healthline’s online newsletter to get helpful tips for managing your condition. You can also find support and advice from our Bezzy RA community.


Should older adults use a lower dose of Kineret?



Possibly. Kineret’s dosing doesn’t depend on age. But doctors may prescribe a lower Kineret dose for people with severe kidney problems, such as end-stage kidney disease (ESRD).

Adults 65 years and older are more likely to have severe problems with their kidneys. The kidneys stop working as you age.

“Your body’s kidneys are responsible for removing Kineret after you inject it. People with severe kidney problems may not be able to clear Kineret from their system. This can increase the risk of side effects. The risk of these side effects may be reduced by using a lower dose.”

“Some older adults don’t need a lower dose of Kineret. Before you start treatment with Kineret, you should have a discussion with your doctor. This should include other conditions, such as the kidneys. Your doctor will use this information to determine the correct dose of Kineret.”

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.