If you have a certain type of lung cancer, your doctor might suggest Lumakras as a treatment option. It’s a prescription drug used to treat a type of non-small cell lung cancer (NSCLC) in adults.

It is used to treat non-smilng lung disease.

  • that’s locally advanced (spread to nearby lymph nodes or tissues outside the lungs) or metastatic (spread to other areas in the body)
  • that has the KRAS G12C gene mutation (abnormal protein in lung cells that helps cancer cells grow)
  • Those who have received at least one type of systemic treatment are more likely to have other health problems.

The active ingredient in Lumakras is sotorasib. An active ingredient is what makes a drug work. It is part of a group of drugs called the RAS GTPase inhibitors.

This article describes the dosages of Lumakras, as well as its strength and how to take it. To learn more about Lumakras, see this in-depth article.

Note: This article covers Lumakras’s usual dosages, which are provided by the drug’s manufacturer. But when taking this drug, always take the dosage your doctor prescribes.

There is a lot of information about Lumakras.

What is the form of Lumakras?

Lumakras is a tablet that you swallow.

What strength does Lumakras come in?

Lumakras is available in one strength.

What are the usual dosages of Lumakras?

The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.

The typical amount of Lumakras is 960 tablets per day. It is best to take your daily dose at the same time each day. Your doctor will monitor you for side effects while you take Lumakras. They will check to make sure the drug is effective in treating your condition.

Is Lumakras taken long term?

Lumakras is a long-term treatment. You will likely take it long term if you and your doctor determine that it is safe and effective for you.

Dosage adjustments

Some people may need to adjust their dosages. Your doctor will explain why you need a dosage adjustment.

If you have There are serious side effects. from Lumakras, dosage adjustments may be necessary. These include:

If you have any of the There are serious side effects. shown, your doctor will stop your Lumakras treatment. They will restart you at a lower Lumakras dosage of 480mg once per day once you have recovered. You can continue at the lower dose if you want to.

If you still experience There are serious side effects., your doctor may again pause your treatment. They may restart Lumakras at the next lower dose of 240 tablets. They will monitor how you do with this dose. If the drug is working, you will probably continue with this dose. If you still have There are serious side effects., they may permanently stop your Lumakras treatment.

Factors that may affect the dosage of Lumakras are listed below. These include:

  • other conditions you may have, such as other lung problems or liver problems (see “Dosage adjustments” directly above)
  • There are serious side effects.
  • The timing of your schedule may need to be adjusted.

You can take Lumakras tablets by mouth. You will swallow eight tablets with water for the 960-mg dose. You can take Lumakras with or without food.

You should not crush, split, or chew the tablets. If you have trouble swallowing pills, place the tablets in 120 milliliters (mL)* of room-temperature water, stir, and drink the entire contents. The tablets won’t fully dissolve, but you should just swallow (not chew) what’s left. Then add another 120 mL of water to rinse the inside of the glass and drink that too to ensure you get the full dose. (You can read the full instructions from the manufacturer of Lumakras here.)

You can also ask your doctor or pharmacist for more information and tips on swallowing pills. Or check out this article.

For information on the expiration, storage, and disposal of Lumakras, see this article.

The 120 mL is 4 ounces.

Accessible drug containers and labels

“If you can’t read the prescription label on your medication, you should tell your doctor or pharmacist. Some pharmacies have labels for medication.”

  • Large print or use of blind.
  • You can use a code on a phone to change the text to sound.

“If your current pharmacy doesn’t offer accessibility features, your doctor or pharmacist may be able to recommend a new pharmacy.”

Let your pharmacist know if you have trouble opening bottles. They may be able to give Lumakras in a container. They may have tips to make it easier to open the drug container.

“If you miss your daily dose, take it as soon as you remember. If it has been more than 6 hours since you missed your dose, then skip it and continue with your next dose. If you vomit your regular dose of Lumakras, don’t take it again.”

And don’t take two doses of Lumakras at once to catch up on a missed or vomited dose. This could cause There are serious side effects.. If you’re concerned about your missed dose, call your doctor’s office.

If you need help remembering to take your dose on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.

Do not take more Lumakras than your doctor prescribes as this can lead to There are serious side effects..

What to do in case you take too much Lumakras

Call your doctor right away if you think you’ve taken too much Lumakras. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

The dosages provided by the drug manufacturer are described in the sections above. If your doctor recommends Lumakras, they will prescribe the correct amount.

Remember, you shouldn’t change your dosage of Lumakras without your doctor’s recommendation. Only take Lumakras exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Some questions you may want to ask your doctor.

  • If I have serious side effects from Lumakras, will my dose change?
  • Is it necessary to have a different dose of Lumakras if I take other medications?
  • Would a lower dosage of Lumakras still work for my type of cancer?


Will I need a dosage adjustment if I have serious liver problems?



Maybe. Your doctor will check your liver function before you begin treatment. Lumakras can increase your liver enzyme levels. In serious but rare cases this can cause liver injury or hepatitis. Tell your doctor about your medical history, including if you’ve had hepatitis or serious liver problems in the past. They’ll help you decide if Lumakras is safe for you.

If you have serious problems with the bile duct, your doctor may start you on a lower dose of Lumakras. This will be dependent on a number of factors, including the severity of your lung condition, the severity of your liver problems, and other individual factors.

Your doctor will continue checking your liver function every 3 weeks for the first 3 months of treatment. Then they’ll check your liver function once per month for as long as you take Lumakras. If you have There are serious side effects., including liver problems, during treatment, your doctor may lower your dose, or pause or stop your treatment.

If you have questions about your dose, talk to your doctor. They can discuss the risks and benefits with you. You should not stop taking this drug on your own.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.