According to the American Migraine Foundation, migraine affects 39 million adults and children in the United States.

Chronic migraine can be debilitating and often has a significant impact on quality of life. One of the best ways to manage this is with medications or therapies meant to prevent migraine episodes.

Options that prevent migraines are referred to as migraines. Some treatments can help reduce the severity of There are There is a throbbing head.s..

In this article, we look at the most common treatment options for migraines and the research on how effective they are.

Angiotensin blockers are drugs that prevent the production of angiotensin, a hormone that causes the blood vessels to narrow.

Angiotensin blockers may include angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs).


In one 2012 study, an ARB called candesartan was shown to reduce not only the number of There is a throbbing head. days, but also There is a throbbing head. hours, migraine days, and migraine hours, compared to placebo.

In another study from 2007, an ACE inhibitor called lisinopril showed significant reductions in migraine frequency and acute medications in study participants.

Side effects

Angiotensin blockers may have side effects.

  • cough
  • dizziness
  • fatigue
  • Lightheadedness.
  • Inflammation of the GI tract.

It can take weeks for long-term benefits to show up.

Anticonvulsant drugs, also known as antiepileptic drugs (AEDs), are medications that help treat and prevent epileptic seizures by slowing nerve signals in the brain.

Anticonvulsant drugs may include narrow-spectrum AEDs for specific types of seizures or broad-spectrum AEDs for multiple seizures.


According to a 2012 review, divalproex sodium and sodium valproate both showed effectiveness in reducing migraine attack rates in clinical studies. Topiramate was also found to significantly reduce migraine frequency in 11 different studies.

Gabapentin, lamotrigine, and oxcarbazepine have shown mixed results in their effectiveness for migraine prophylaxis.

Side effects

There are some common side effects of the AED.

  • There is a rash.
  • fatigue
  • Increased power.
  • Inflammation of the GI tract.
  • paresthesia
  • weight gain
  • hair loss

It can take up to 8 weeks for a prophylactic to work for migraines.

Antidepressants are medications that treat depression, anxiety, and other mental health conditions by altering the neurotransmitters in the brain.

Antidepressant medications commonly include selective serotonin reuptake inhibitors (SSRIs) and serotonin and norepinephrine reuptake inhibitors (SNRIs), as well as other medications.


In an early study, an SSRI called fluoxetine was shown to significantly reduce the pain index after several months of treatment.

A more recent review from 2015 noted an SNRI called venlafaxine demonstrated a reduction in migraine intensity and duration over several studies.

Amitriptyline, a tricyclic antidepressant, was also found to be effective for migraine prophylaxis.

Side effects

The side effects of The drugs antidepressants may be common.

  • nausea
  • vomiting
  • It is not good to be It is not good to be It is not good to be drowsiness…
  • The mouth is dry.
  • Difficult concentrating
  • The heart rate went up.

The drugs antidepressants can take up to 6 weeks to show benefits.

Beta-blockers are medications that reduce heart rate and blood pressure by blocking the actions of the hormone adrenaline (epinephrine).

The most commonly prescribed medication for migraines is ble-blockers.


Multiple studies have found metoprolol to be effective for reducing migraine frequency by as much as 50 percent.

A 2019 study on propranolol also found this medication to be effective in reducing migraine frequency, duration, and severity.

Other potential There areblockers. for migraine prevention include timolol and atenolol.

Side effects

There are some common side effects of theblockers.

  • The mouth is dry.
  • It is not good to be It is not good to be It is not good to be drowsiness…
  • fatigue
  • weight gain
  • sleep problems

It can take months for a preventive medication to work.

A drug that can be used to treat a condition., or botulinum toxin type A, is an injectable drug produced by the bacterium Clostridium botulinum, which temporarily weakens or paralyzes the muscles.

otulinumtoxinA can be used to treat certain medical conditions, such as chronic migraines.


In one systematic review, researchers analyzed the data from 28 trials on the effectiveness of A drug that can be used to treat a condition. for migraine prevention. Studies included those comparing A drug that can be used to treat a condition. to a placebo, as well as those comparing A drug that can be used to treat a condition. to other prophylactic treatments.

The analysis found that the use of theotulinumtoxinA was able to reduce There are There is a throbbing head.s. by 2 per month.

Side effects

There are some common side effects ofotulinumtoxinA.

  • The injection site has pain.
  • The eyelid is sagging.
  • Weakness in the muscles.
  • The neck hurts.

After 4 weeks, the most effective time for A drug that can be used to treat a condition. to work is, with most trials recording results after 12 weeks.

Calcitonin gene-related peptide (CGRP) therapy uses monoclonal antibodies to reduce the inflammation and pain associated with chronic migraine episodes.

renumab is the most common medication used for migraines.


In one large trial, researchers assigned over 900 study participants with chronic migraine with either 70 milligrams (mg) erenumab, 140 mg erenumab, or a placebo.

For 20 weeks, erenumab was used to determine the effectiveness of reducing the number of migraines.

The results showed that erenumab was able to reduce the number of days with migraines.

Side effects

Common side effects of CGRP may include:

  • The injection site has pain.
  • There are frequent upper respiratory infections.
  • Consuming food issues.
  • fatigue
  • nausea

CGRP generally shows results for migraine prevention within the first 2 months, with effectiveness becoming stronger over time.

Nonsteroidal anti-inflammatory drugs (NSAIDs) are medications that help reduce inflammation and pain by blocking the production of prostaglandins.

NSAIDs are most commonly used for the prevention of menstrual migraine (migraine attacks that occur with menstruation).


According to evidence-based guidelines from the American Academy of Neurology and the American Headache Society, NSAIDs show modest benefits for the prevention of migraine attacks.

Clinical trials have shown benefits for Naproxen sodium, flurbiprofen, and mefenamic acid.

However, long-term, daily use of NSAIDs is not always recommended for migraine prophylaxis, as it can lead to medication overuse There are There is a throbbing head.s..

Side effects

Common side effects of NSAIDs may include:

  • Inflammation of the GI tract.
  • There are There is a throbbing head.s.
  • It is not good to be It is not good to be It is not good to be drowsiness…
  • dizziness
  • Damage organ is rare.

NSAIDs should be taken 2 to 3 days before menstruation and the first 2 to 3 days after.

Triptans, also known as serotonin-receptor agonists, are medications that help relieve inflammation by mimicking the actions of the neurotransmitter serotonin.

Tripsans are more suitable for short-term applications than sennas.


In a 2008 study, frovatriptan was found to be effective at reducing migraine frequency in study participants.

Another study found that naratriptan was effective at reducing menstrual migraine attacks when taken 2 days before menstruation and 3 days during.

Zolmitriptan was also found to be effective at reducing the frequency of migraine attacks according to 2014 study.

Side effects

There are some common side effects of Tripstans.

  • There is a throbbing head.
  • dizziness
  • nausea
  • fatigue

Tripsan can show effectiveness for migraines in a matter of hours.

In addition to the medication options discussed above, certain vitamin and herbal supplements may also offer benefits for migraine prevention. These include:


According to the research, butterbur is the most effective herbal supplement for reducing frequency and severity of migraine attacks.

In addition, It was a bit cold., The magnesium., and riboflavin have shown effectiveness for migraine prophylaxis in research studies.

Other supplements, such as CoQ10, may be effective, but more research is needed.

Side effects

If you are taking a medication that is not interacting with a health condition, or if you are taking a supplement that is not directed, it is not likely that you will have side effects.

You should always talk with a doctor before taking any supplements.

Vitamin supplement Possible side effects
CoQ10 mild insomnia or digestive upsets
butterbur gas, There is a throbbing head., itchy eyes, diarrhea, breathing difficulties, fatigue, upset stomach, It is not good to be It is not good to be It is not good to be drowsiness…
It was a bit cold. nausea, digestive problems, bloating; people sensitive to ragweed may experience allergic reactions
The magnesium. loose stools, stomach upset, nausea (people with kidney issues are at a higher risk of experiencing side effects)
melatonin is a sleep hormone It is not good to be It is not good to be It is not good to be drowsiness…, dizziness, There is a throbbing head. and nausea
B2 is a vitamins. high doses may cause itchiness, numbness, burning/prickly sensations, orange urine, sensitivity to light
B12 is a vitamins. mild diarrhea, itching skin There is a rash., There is a throbbing head., dizziness, nausea vomiting
The amount of the D is low. excessive amounts (over the daily recommended dose) may lead to hypercalcemia; symptoms include There are There is a throbbing head.s., fatigue, excessive thirst, excessive urination, nausea, vomiting, decreased appetite.

It can be difficult and frustrating to choose the right treatment option for chronic migraines, because of the trial and error involved.

Your doctor will work with you to find the medication that will work for you.

Preventive medications are usually started at a low dose and adjusted up over time. The best results for the most popular medications for migraine are seen after about 6 months.

The goal of migrants is to reduce the number of headaches by 50 percent.

Migraine prevention can include more than just preventive medications. Changes in lifestyle can help prevent recurring headaches.

There are some best practices for preventing chronic migraines.

  • Keep a diary of known triggers. Creating a There is a throbbing head. diary is an important step in being able to identify and avoid your migraine triggers. Consider trying a migraine app for tracking migraine triggers and patterns.
  • Consider complementary therapies. Complementary treatment options for migraine, such as acupuncture or acupressure, may provide additional symptom relief.
  • Practice good sleep hygiene. Poor sleep is one of the most common triggers for migraine, so practicing good sleep hygiene plays a crucial role in migraine prevention.
  • Engage in regular exercise. Research has shown that gentle exercise practices, such as yoga, may help reduce the frequency and severity of chronic migraine.
  • Prioritize relaxation. Stress is another known trigger for people with recurrent migraine attacks, so stress management skills are an important tool for prevention.
  • Treat migraine attacks as soon as possible. Migraine prophylaxis doesn’t mean that you’ll never have another migraine, so it’s important to keep emergency medication on hand for when migraine attacks inevitably develop.

You should work with a doctor to create a plan that works for you.

What is the meaning of migraine prophylaxis?

Migraine prophylaxis is the use of any treatment or medication that is used to prevent migraines from happening.

Which drug is used for prophylaxis of migraine?

There are a number of medication options for the prevention of migraines.

  • Angiotensin blockers are used.
  • Anticonvulsants.
  • The drugs antidepressants
  • There areblockers.
  • A drug that can be used to treat a condition.
  • The therapy uses a conjugate gene-related peptide.
  • NSAIDs are anti-Inflammatory drugs.
  • Tripstans
  • vitamins and supplements

What is the best prophylaxis for migraine?

The best way to prevent migraines is with the one that works for you. Different people may have different needs. A combination of strategies is the most useful over time.

Migraine prevention is one of the most important treatment approaches for reducing the occurrence of recurrent headaches.

Preventive treatment options for migraine include medications such as The drugs antidepressants, Anticonvulsants., There areblockers., and more.

lifestyle changes are an important part of the prevention of migraines.

If you have been having chronic migraines that have made you feel unwell, talk to your doctor about which preventive treatment options are available to you.