Ofev is a treatment option for lung disease. It is a prescription drug used in adults.
- to treat pulmonary fibrosis from an unknown cause
- to treat long-term interstitial lung disease with scarring
- to slow worsening lung function from interstitial lung disease associated with systemic sclerosis
Ofev is a capsule that contains the active ingredient nintedanib. An active ingredient is what makes a drug work. It is a drug that is in a group of drugs called tyrannomycin.
This article describes the dosages of Ofev, as well as its strengths and how to take it. To learn more about Ofev, see this in-depth article.
Note: This chart highlights the basics of Ofev’s dosage. Be sure to read on for more detail.
|Ofev form||Ofev strength||Usual dosage|
|capsule||• 100 milligrams (mg)
• 150 mg
|150 mg twice per day|
Please keep in mind that this article covers Ofev’s standard dosing schedule, which is provided by the drug’s manufacturer. But always follow the dosage instructions your doctor prescribes.
The information below describes dosages that are commonly used or recommended. But be sure to take the dosage your doctor prescribes for you. They’ll determine the best dosage to fit your needs.
What is Ofev’s form?
Ofev is a capsule.
What strengths does Ofev come in?
Ofev has two strengths: 100 and 150.
What are the usual dosages of Ofev?
The recommended dosage for adults is the same for all of the conditions it’s approved to treat. But Ofev’s prescribing information provides dosage assistance for adjustments in people with liver problems. Your doctor will prescribe the dosage that’s right for you.
“The administration of your dose is done by someone. It is not usually given in your doctor’s office.”
Dosage for long-term interstitial lung disease with scarring
To treat interstitial lung disease* with scarring, the usual dosage of Ofev is 150 mg two times per day. This is also the recommended maximum dosage (300 mg per day).
*This is a group of conditions that cause inflammation and scarring of the lung tissue.
Dosage for interstitial lung disease associated with systemic sclerosis
To slow worsening lung function from interstitial lung disease associated with systemic sclerosis,* the usual dosage of Ofev is 150 mg twice per day. This is also the recommended maximum dosage (300 mg per day).
*This is a condition where too much collagen (a kind of protein) is produced by your body.
Dosage for pulmonary fibrosis from an unknown cause
Idiopathic pulmonary fibrosis is a kind of interstitial lung disease from an unknown cause where scar tissue builds up in your lungs. To treat this condition, the usual dosage of Ofev is 150 mg two times per day. This is also the recommended maximum dosage (300 mg per day).
Is Ofev taken long term?
Ofev is usually prescribed for a long time. If you and your doctor agree that it is safe and effective for your condition, you will likely take it for a long time.
If you have mild liver problems, your doctor may prescribe a lower dosage of Ofev for you. Before you start treatment, you’ll take a blood test to see how well your liver is working. Depending on the severity of your liver problems, your doctor may prescribe a lower dosage of Ofev. Or they may recommend a different treatment option for you.
Your doctor will recommend the correct amount of Ofev to you, as well as how often you take it.
Twice per day is how much ofev is taken. The timing of your doses should be staggered. Ofev should be taken with food.
“Ofev should be swallowed whole. Do not chew the capsule. Don’t touch the contents of the capsule. If you come in contact with the contents of Ofev capsule, wash your hands immediately.”
For information on the expiration, storage, and disposal of Ofev, see this article.
If you have trouble swallowing capsules, see this article for tips on how to take this form of medication.
Accessible drug containers and labels
“If you can’t read the prescription label on your medication, you should tell your doctor or pharmacist. Some pharmacies have labels for medication.”
- Large print or use of blind.
- You can use a code on a phone to change the text to sound.
“If your current pharmacy doesn’t offer accessibility features, your doctor or pharmacist may be able to recommend a new pharmacy.”
Let your pharmacist know if you have trouble opening bottles. They may be able to deliver Ofev in a container. They may have tips to make it easier to open the drug container.
The amount of Ofev you are prescribed may be affected by a number of factors. These include:
- if you have liver problems
- You may experience some side effects from Ofev.
- You may have other conditions.
- You take other drugs.
If you miss a dose, skip it. Take your next dose at the usual time. You should not take two Ofev at the same time. Doing so can increase your risk of side effects.
If you need help remembering to take your dose of Ofev on time, try using a medication reminder. This can include setting an alarm or downloading a reminder app on your phone.
If you take more Ofev than your doctor prescribes, you can have serious side effects.
What to do in case you take too much Ofev
Call your doctor right away if you think you’ve taken too much Ofev. You can also call 800-222-1222 to reach the American Association of Poison Control Centers or use its online resource. But if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.
There are answers to some questions about Ofev.
If Ofev isn’t working well enough for me, will my doctor increase my dosage?
The recommended dose of Ofev is not likely to be increased. The maximum daily dose is 300mg per day.
“100 of Ofev may be prescribed by your doctor twice per day. If that isn’t working, they may recommend increasing your dose to 150 percent of your body weight twice a day. This will be dependent on your situation.”
In studies, Ofev was found to be effective for the conditions it was approved to treat. But if it’s not working well enough for you, talk with your doctor. They may recommend you come in for a checkup or suggest a different treatment option.
Smoking and taking other drugs can affect Ofev. Examples include:
- phenytoin (Dilantin)
- carbamazepine (Carbatrol, Equetro, Tegretol)
- rifampin is a drug
- the supplement St. John’s wort
To learn more about drugs that may interact with Ofev, see this in-depth article.
Will my doctor lower my dosage if I have side effects from Ofev?
Possibly. In most cases, mild side effects should be temporary. And some may be easily managed. But if your side effects are more severe, your doctor may recommend that your dose of Ofev be reduced to 100 mg twice per day. Or they may have you temporarily stop taking the drug. To learn more about Ofev’s side effects, see this in-depth article.
If your side effects go away or become less severe, your doctor may increase your dose to 150 or more times per day. Your doctor will likely stop your treatment if your side effects continue at the lower dosage.
Liver damage is a serious side effect of Ofev. Your doctor will order blood tests to check your liver function before you start taking Ofev and during treatment. If you develop liver problems while taking this drug, your doctor will likely reduce your dosage or have you stop taking it.
There are some symptoms of liver damage.
- There is a problem of jaundice.
- bleeding or bruising easily
- appetite loss
- The right belly is hurting.
- fatigue (low energy)
- Dark colored urine.
The dosages provided by the drug manufacturer are described in the sections above. If your doctor recommends Ofev, they will prescribe the correct amount.
Remember, you should not change your dosage of Ofev without your doctor’s recommendation. Only take Ofev exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.
Some questions you may want to ask your doctor.
- How will my doctor change my Ofev dosage if my liver isn’t working well?
- Will my age affect my medication?
- Will my doctor change my medication regimen if I take other drugs?
Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.