If you have episodic migraine, your doctor might suggest Qulipta as a treatment option. It’s a prescription drug used to prevent migraine episodes in adults.

Qulipta is a tablet that you swallow and contains an active ingredient. An active ingredient is what makes a drug work.

If Qulipta works to prevent migraines, your doctor will recommend you take it for a long time.

For more information about Qulipta, see this in-depth article.

Qulipta can cause mild to serious side effects. Continue reading to learn more.

Some people may experience side effects during their treatment. Qulipta has been reported to have some side effects.

The side effects explained section is where you can learn more about this side effect.

Mild side effects can be caused by Qulipta. Some examples have been reported.

The side effects explained section is where you can learn more about this side effect.

“These side effects should be temporary. Some may be easy to manage. If you have any symptoms that bother you, talk to your doctor or pharmacist. Unless your doctor recommends it, don’t stop taking Qulipta.”

Qulipta may cause mild side effects other than those listed above. See the drug’s prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Qulipta, visit MedWatch.

Serious side effects were not reported in studies of people taking Qulipta. But it’s still possible that you could have serious side effects from this drug. It’s also possible to experience an allergic reaction, though it’s not clear whether this side effect occurred in Qulipta’s studies.

If you develop serious side effects while taking this drug, call your doctor. If they seem life threatening or you think you have a medical emergency, call the emergency number.

There are answers to some questions about Qulipta.

Does Qulipta cause Weight loss or weight gain.?

Weight gain was not a reported side effect in people taking Qulipta in studies. You may experience weight loss from taking this drug, which may be because the drug can cause a decrease in appetite. But this was not one of the most common side effects that people using Qulipta reported.

“If you notice that you have lost weight, talk to your doctor. They can help you figure out what’s causing the weight change.”

Is hair loss a side effect of Qulipta?

No, hair loss was not reported by people taking Qulipta in studies. But other drugs used to prevent migraine may cause hair loss. These include:

If you notice hair loss, talk to your doctor. They can help figure out what is causing it. They can recommend ways to treat hair loss, such as using minoxidil.

Will taking Qulipta cause dizziness?

No, dizziness was not a side effect that people taking Qulipta reported in studies. But it may be a side effect of migraine itself. In addition to severe head pain, migraine can cause symptoms such as dizziness, nausea, or vision changes.

If you have dizziness while taking Qulipta, talk to your doctor. They can help determine what is causing the symptom and suggest a treatment.

Does Qulipta cause depression?

No, depression was not a side effect reported in studies of people taking Qulipta. But some drugs used to prevent migraine, such as Depakote (divalproex), may cause changes in mood, including depression.

And you may have an increased risk of depression if you have migraine.

If you notice symptoms of depression, talk to your doctor. Symptoms may include:

  • “It’s sad or lonely.”
  • Sleeping less often is also a thing.
  • Weight loss or weight gain.
  • You lost interest in activities you used to enjoy.

Your doctor can help you determine what may be causing your depression. They may also be able to recommend ways to treat it, such as taking an antidepressant.

Some of the side effects Qulipta may cause are discussed.


You may have nausea from taking Qulipta. It was one of the most common side effects reported in studies of the drug. And you may be at an increased risk of this side effect if you’re taking a higher dose of Qulipta.

Nausea may also be a migraine symptom. So if you’re unsure about what’s causing your nausea, talk with your doctor. They can help you determine the cause.

What might help

Tell your doctor if you have nausea while taking Qulipta. They may be able to recommend ways to reduce the side effect. They may recommend taking a lower dose of Qulipta to see if it helps with nausea.


Constipation was one of the most common side effects reported in Qulipta studies. You may be constipated if you have:

What may help

If you have constipation that’s severe or bothersome, talk with your doctor. They’ll be able to suggest ways to reduce this side effect. For example, they may recommend increasing your water consumption or using an over-the-counter medication, such as MiraLax (polyethylene glycol).

Increased liver enzymes

Although it wasn’t common, it’s possible to develop an increase in the level of liver enzymes in your blood during Qulipta treatment. This increase in liver enzymes may indicate liver problems, so it’s important to tell your doctor right away if you notice any symptoms of liver damage, including:

What might help

People with increased liver enzymes did not report symptoms of their own. Your doctor may check your blood levels during your treatment.

If you do develop symptoms of liver damage, tell your doctor right away. They’ll likely do a blood test to see if your symptoms are related to your liver enzymes. If they find that your liver enzyme levels have increased, they may have you stop taking Qulipta and try a different migraine prevention treatment.

Allergic reaction

Qulipta can cause an allergic reaction in some people. It is not clear if this side effect occurred in studies.

Mild to serious symptoms can be present.

  • There is a skin rash.
  • It is itchy.
  • flushing (temporary warmth, redness, or deepening of skin color)
  • “It’s usually under your skin, but it can be anywhere.”
  • It can be hard to breathe if you have swelling of your mouth, tongue, or throat.

What might help

If you have a mild rash, call your doctor. They may suggest a treatment to help you. Examples include:

  • an antihistamine you take by mouth, such as Benadryl (diphenhydramine)
  • You apply a cream to your skin.

If your doctor confirms that you have an allergic reaction to Qulipta, they will decide if you should continue taking it.

If you have a severe allergic reaction, you should call the emergency number. These symptoms could be life threatening and need immediate medical care.

If your doctor confirms you have a serious allergic reaction to Qulipta, they may have you switch to a different treatment.

Keeping track of side effects

Take notes on any side effects you are having during your Qulipta treatment. You can share this information with your doctor. This is helpful when you are starting to use a combination of treatments.

Side effect notes can include things.

  • When you had the side effect, what dose of the drug was taking?
  • How soon did you experience the side effect?
  • What are your symptoms?
  • How did it affect your daily activities?
  • What other drugs were you taking?
  • Other information is important to you.

Sharing your notes with your doctor will help them learn more about Qulipta. If needed, they can use this information to adjust your treatment plan.

If you have certain medical conditions, Qulipta may not be right for you. These are drug-condition interactions. Qulipta is a good treatment option if you have other factors to consider. Before starting Qulipta, you should talk to your doctor about your health history. Some factors to consider.

Kidney problems. If you have kidney problems, tell your doctor before starting Qulipta. Your kidneys help remove Qulipta from your blood. If you have kidney problems, you may not be able to get rid of the drug. This can cause it to build up in your body, which may increase your risk of side effects. Due to this risk, your doctor may recommend a lower dose of Qulipta if you have kidney problems.

Allergic reaction. If you’ve had an allergic reaction to Qulipta or any of its ingredients, your doctor will likely not prescribe it for you. Ask them about other medications that might be better treatment options.

Liver problems. Tell your doctor if you have any liver problems before starting treatment with Qulipta. This medication is broken down in your body by your liver. If you have a liver problem, your body may not be able to get rid of Qulipta like it should. This can cause the drug to build up, which may increase your risk of side effects. Due to this risk, your doctor may recommend a different migraine-prevention medication. (For more information see “Increased liver enzymes” under “Side effects explained” above.)

Alcohol and Qulipta

There are no known interactions between alcohol and Qulipta. But drinking alcohol while you’re taking Qulipta may cause your side effects to get worse. For example, both alcohol and Qulipta can cause nausea, so both together may increase your risk of this side effect.

In addition, alcohol may be a migraine trigger for some people (meaning alcohol may cause migraine episodes).

Talk to your doctor about the risks of drinking alcohol while you are in treatment.

Pregnancy and breastfeeding while taking Qulipta

“Qulipta is not known if it is safe to take during a pregnant woman’s time. There are no studies done on pregnant women to see if the drug is safe. There are no studies to determine if Qulipta is present in human breastmilk or if it has effects on a breastfeeding child.”

“If you are pregnant, you should talk with your doctor before taking Qulipta. They can help you determine if it’s safe for you.”

Side effects from Qulipta are usually mild. Before you start treatment with this drug, you should talk to your doctor about any questions you have. Here are a few examples to help you get started.

  • How should I treat the side effects of Qulipta?
  • Is this drug riskier for me due to my other medical conditions?
  • If I have side effects from this drug, can I try another calcitonin gene-related peptide (CGRP) antagonist treatment such as Ubrelvy (ubrogepant)?

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If I’m also taking medication to treat migraine, am I at an increased risk of side effects from Qulipta?



It is possible, but it depends on the other drug you are taking and the possible side effects it may cause.

Qulipta may cause side effects such as nausea, constipation, and fatigue (low energy). So if your migraine treatment also causes these symptoms, your risk of side effects may be increased if you take Qulipta along with it.

If you are concerned about side effects during your treatment, talk to your doctor.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.