If you have migraine, your doctor might suggest Treximet as a treatment option for you. It’s a prescription drug used to treat migraine with or without aura in adults and some children.

The active ingredients in Treximet are sumatriptan and naproxen. Active ingredients are what make a drug work.

When you have a migraine, Treximet is a pill that you swallow. It is not meant to be taken every day, but it may be used as needed.

For more information about Treximet, including details about its uses, see this in-depth article.

Like other drugs, Treximet can cause mild to serious side effects. Common side effects of Treximet include The mouth is dry. and dizziness. Keep reading to learn more.

Some people may experience side effects during their treatment. Some reported side effects include:

Treximet may cause a number of side effects. Side effects will not happen to everyone.

Mild side effects have been reported with Treximet use.

“These side effects should be temporary. Some may be easy to manage. If you have any symptoms that bother you, talk to your doctor or pharmacist. Unless your doctor recommends it, don’t stop taking Treximet.”

Treximet may cause mild side effects other than the ones listed above. See the Treximet prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Treximet, visit MedWatch.

Treximet can cause serious side effects.

Treximet use has been reported with serious side effects.

If you develop serious side effects while taking Treximet, call your doctor. If the side effects seem life threatening or you think you have a medical emergency, immediately call the emergency number.

* Treximet has a boxed warning for this side effect. This is the most serious warning from the Food and Drug Administration (FDA). To learn more, see the “Side effects explained” section below.
† To learn more about this side effect, see the “Side effects explained” section below.
‡ An allergic reaction is possible after taking Treximet. But it’s not clear whether this occurred in studies.

“Treximet is used in children. Treximet’s side effects were reported in both adults and children, but the following were only reported in children.”

Hot flashes

Hot flashes (also called hot flushes) were a rare side effect in children participating in Treximet studies. This side effect happened more often in children who took a higher dosage.

Hot flashes last a few minutes and go away on their own. There are symptoms of a hot flash.

What might help

There are a few tips that may help relieve the hot flashes.

  • The child should drink ice water.
  • They should be dressed in layers that are easy to remove.
  • They should wear cotton or other fabrics.
  • Offer them a cold pack.

If your child has hot flashes, you should talk to their doctor. They may be able to suggest other ways to make this less annoying.

Tight muscles

In studies, The muscles are tight. were a rare side effect that happened in children who took the highest dosage of Treximet.

Muscle tightness may be related to how Treximet works to treat migraine. It can also be a sign of a rare condition called serotonin syndrome. (See “Side effects explained” below for more information about this condition.)

What might help

It is usually a matter of muscle tightness going away on its own. You can help by having the child move around. If you have a migranes try massaging the tight muscle. Staying hydrated helps prevent muscle tightness.

“If the muscle tightness doesn’t go away, you should call your child’s doctor. If your child has a chest or jaw ache, or any other symptoms that might indicate a medical emergency, you should call the police or the hospital.”

Get answers to questions about Treximet.

Can Treximet cause long-term side effects?

Yes, it’s possible for Treximet to cause long-term side effects. This is more likely if you take Treximet over a long period. Serious long-term side effects were rare in studies of Treximet, though.

Side effects that could last for a long time.

  • Side effects that start during the treatment and continue for a long time, possibly after the treatment ends. For example, if you have a rare heart or blood vessel side effect of Treximet, it could need medical care for a long time.
  • Side effects that start after you’ve taken the drug for a long time or after the treatment ends. For example, a There is over use of medication. can happen if you’ve taken Treximet too frequently over a period of a few months or longer. This can lead to chronic migraine.

Migraine can be painful and disrupt your life. So the risk of long-term side effects is not usually a reason to avoid treatment. You can learn about the risks and possible benefits of different treatments in this article or by talking with your doctor.

Can Treximet make my migraine episodes worse?

A There is over use of medication. is a migraine headache or another headache that gets worse after you take medication to relieve it.

It’s been reported with sumatriptan, one of the active ingredients in Treximet. It usually happens when you take the following types of drugs:

“If you take these medications at least 10 days a month, you’re more likely to have this side effect. If you need to take Treximet more than 10 days a month, you should talk to your doctor. A treatment that helps prevent headaches may be beneficial.”

Will taking sumatriptan and naproxen separately reduce my risk of side effects?

It depends. Sumatriptan and naproxen, the two active ingredients in Treximet, can cause different side effects. Some side effects reported in studies of Treximet are known to stem from only one of the active ingredients. For example:

There are other things to consider. Some people prefer to keep track of one pill. Some people have better relief from migraines when they take 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 888-349-8884 Others do well on their own. Discuss the best ways to reduce the effects of your treatment with your doctor.

Treximet may cause some side effects.

Risk of heart and blood vessel problems

Treximet has a boxed warning about the risk of heart and blood vessel problems, such as a heart attack or stroke. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). Due to this risk, doctors will not prescribe Treximet if you’ve recently had or are planning to have a heart surgery called a coronary artery bypass graft (CABG).

Treximet contains the active drug naproxen, which is a nonsteroidal anti-inflammatory drug (NSAID). In studies of people who’d undergone CABG, NSAIDs such as naproxen increased the risk of a heart attack when taken 10 to 14 days after the surgery.

Treximet also contains the active drug sumatriptan. Taking NSAIDs or drugs such as sumatriptan can increase your risk of serious heart and blood vessel problems. These side effects are more likely to occur in older adults and those with certain other medical conditions. Symptoms of these side effects are below.

There are symptoms of stroke.

  • “It’s hard talking.”
  • slurred speech
  • On one side of your face.
  • The arm is weak on one side.

There are some symptoms of a heart attack.

This is not a complete list of the possible symptoms. And the symptoms of a heart attack are often different in females and males.* Read this article to learn more about the similarities and differences.

* In this article, we use the terms “male” and “female” to refer to someone’s sex assigned at birth. For information about the difference between sex and gender, see this article.

What might help

Doctors will not prescribe Treximet if you have a heart or blood vessel problem.

Your doctor will look at your medical history to decide if you should be prescribed Treximet. You may need to take tests to make sure your heart is healthy before you start treatment. If you have an increased risk of these side effects, your doctor may give you the first dose of Treximet. They can observe your body reaction to the drug.

This is a medical emergency if you think you are having a heart attack. You should call the emergency number or the emergency room.

Discuss your risk of a serious heart or blood vessel problem with your doctor. It helps to know what to look for when there are these side effects.

Risk of digestive system problems

Treximet has a boxed warning for the risk of digestive system problems. A boxed warning is the most serious warning from the FDA.

One of the active ingredients in Treximet is naproxen, which belongs to a group of drugs called NSAIDs. This boxed warning is based on studies of NSAIDs, but digestive system problems rarely happened in studies of Treximet.

NSAID can cause serious problems in your bicyle. If you take an NSAID for a long time, you are more likely to have serious problems. These problems are related.

These problems can be very dangerous.

If you do, you are more likely to have serious problems.

While There was bleeding. in your stomach or intestines is rare, it is serious. Symptoms include:

What might help

Your doctor will look at your medical history to decide if you should get Treximet. Talk to them about ways to reduce your risk of side effects.

Risk of The flow of blood. problems in your feet or legs

Blood flow problems in the feet or legs was a rare side effect in studies of triptan medications. Sumatriptan is a triptan and one of the active ingredients in Treximet. (An active ingredient is what makes a drug work.)

Blood flow problems can lead to nerve damage if not treated. Symptoms include:

  • A cold feeling in your feet.
  • Your legs or feet change in color.
  • When you are not moving, there is pain in your toes.
  • Leg muscles are heavy or tight.
  • “It’s pain in your legs or hips.”
  • There are sensations in your legs.

What might help

If you have any of the symptoms, call your doctor. If they confirm that Treximet is causing your symptoms, they may suggest a different medication.

There are also ways to improve your circulation. Regular exercise and stretching can help. And if you spend a lot of time sitting or lying down, it can help to take frequent breaks just to move around. If you There is smoke., quitting can also help improve your circulation.

Treximet may also cause The flow of blood. problems in parts of your body other than your legs and feet. Talk with your doctor about serious signs of heart or blood vessel problems to watch out for.

Serotonin syndrome

Serotonin syndrome (a high level of the chemical serotonin) was a rare side effect in studies of triptan medications. Sumatriptan, one of the active ingredients in Treximet, is a triptan medication.

The chemical serotonin is used by your body to regulate certain functions.

  • The temperature.
  • digestion
  • The mood is not good.
  • breathing
  • The flow of blood.

Serotonin syndrome has symptoms.

What might help

Serotonin syndrome may be mild to severe. Severe symptoms, such as a There was a seizure. or hallucinations, are an emergency and may require immediate treatment at a medical facility.

Talk to your doctor about how to recognize the symptoms of a mental illness. If you think you have symptoms of this condition, and they feel life threatening, you should go to the nearest emergency room or call the police.

Allergic reaction

Like most drugs, Treximet can cause an allergic reaction in some people. While it doesn’t appear that this occurred in studies, it can happen.

Mild to serious symptoms can be present.

  • There is a skin rash.
  • It is itchy.
  • flushing (temporary Warm, redness, or deepening of skin color)
  • “It’s usually under your skin, but it can be anywhere.”
  • It can be hard to breathe if you have swelling of your mouth, tongue, or throat.

Severe, life threatening skin reactions can be involved in rare cases of an allergic reaction to Treximet.

These serious skin reactions can include symptoms.

  • There was bleeding. or blisters affecting your eyelids, lips, mouth, nose, or genitals
  • It can be peeling or stinging the skin.
  • The skin is discolored or red.
  • swelling in your face

What might help

If you have a mild rash, call your doctor. They may suggest a treatment to help you. Examples include:

  • an over-the-counter oral antihistamine, such as Benadryl (diphenhydramine)
  • A product that is applied to the skin.

If your doctor confirms that you have had a mild allergic reaction to Treximet, they will decide if you should continue taking it.

If you have a severe allergic reaction, you should call the emergency number. These symptoms could be life threatening and need immediate medical care.

If your doctor confirms that you have had a serious allergic reaction to Treximet, they may have you switch to a different treatment.

Keeping track of side effects

Keep notes about any side effects you have during your Treximet treatment. You can share this information with your doctor. This is helpful when you are starting to use a combination of treatments.

Side effect notes can include things.

  • What was the dose of the drug you were taking?
  • How soon did you experience it?
  • What are your symptoms?
  • How did they affect your daily activities?
  • You were taking any other medications?
  • Other information is important to you.

Sharing your notes with your doctor will help them learn more about Treximet. If needed, they can use this information to adjust your treatment plan.

The FDA has warnings for Treximet. There are serious warnings about the risks of the treatment.

Boxed warnings

Treximet has boxed warnings about the risk of heart and blood vessel problems and the risk of digestive system problems. Boxed warnings are the most serious warnings from the FDA.

To learn more about these risks, see the “Side effects explained” section above.

Other warnings

If you have a medical condition that affects your health, Treximet may not be right for you. Before Treximet treatment starts, talk to your doctor about your health history. The list has factors to consider.

Abnormal heart rhythm. If you have a medical condition that affects your heartbeat or heart rhythm, Treximet might not be safe for you. Ask your doctor if this treatment is safe for your heart. They may monitor your heart rhythm or choose a different medication for you.

Heart failure. If you have heart failure, you may be more likely to have side effects of Treximet. Talk with your doctor about how to decrease your risk. They may monitor you closely or choose a different treatment option for you.

High blood pressure. If you have high blood pressure., Treximet could make it worse. If your blood pressure isn’t being managed, doctors typically won’t prescribe Treximet for you. Talk with them about keeping track of your blood pressure or treating it with medication.

Liver or There are problems with the kidneys.. Treximet may cause liver damage. People with severe liver damage should not take this drug. And because your kidneys remove the drug from your body, it may not be a safe treatment option if you have kidney damage. Talk with your doctor about your kidney and liver function before you take Treximet.

Asthma that is worsened by aspirin or NSAIDs. Some people have asthma attacks that are triggered by NSAIDs. This is more common with aspirin, which is part of the NSAID group. If your asthma is triggered or worsened by an NSAID, Treximet may not be right for you, since it contains the NSAID naproxen. Talk with your doctor about your risk if you have asthma and are considering Treximet.

Allergic reaction. If you’ve had an allergic reaction to Treximet or any of its ingredients, your doctor will likely not prescribe it for you. Ask them what other medications are better treatment options.

Blood flow problems. Doctors likely will not prescribe Treximet for you if you have a medical condition that causes slow or irregular The flow of blood., such as:

This is because taking Treximet could make your The flow of blood. problems worse. Talk with your doctor about other migraine treatments if you have The flow of blood. problems.

Alcohol use and Treximet

You should not Drink alcohol. while taking Treximet. Alcohol and naproxen can increase the risk of There was bleeding. in your stomach.

Talk with your doctor if you have questions about alcohol and your risk of stomach and intestinal There was bleeding. from Treximet.

Pregnancy and breastfeeding while taking Treximet

Treximet is not safe to take after week 30 of pregnancy. It’s known to cause problems with the development of the fetal heart. Treximet may also affect amniotic fluid (liquid that surrounds the fetus) after week 20 of pregnancy. Talk with your doctor about the risks and benefits of this and other migraine treatments during pregnancy.

If you are sexually active while taking Treximet, you should talk to your doctor about birth control.

“Treximet has been shown to be present in milk. Treximet can be used while breastfeeding, so it’s important to talk to your doctor about the risks and benefits.”

While there are reports that Treximet has caused serious side effects, most side effects are usually mild. You can discuss what to expect with your doctor. Here are a few ideas of questions to ask them.

  • Will my side effects be worse if I take Treximet more often?
  • Does Treximet cause worse side effects than other migraine medications?
  • Treximet side effects usually last a long time.
  • What can I do to prevent side effects?

For tips about managing your condition, sign up for Healthline’s migraine newsletter. And if you’re looking for advice and stories from others living with migraine, consider joining Bezzy Migraine, an online community.

Q:

Does Treximet have different side effects from other triptan medications?

Anonymous

A:

Yes, Treximet might have different side effects from other Tripstans. Treximet contains two active ingredients: sumatriptan and naproxen. Each of these ingredients can cause side effects.

For example, naproxen can cause a rare side effect of There was bleeding. in the stomach or intestines, which isn’t a side effect of sumatriptan when taken alone.

Sumatriptan belongs to a group of migraine medications called Tripstans. Some examples of Tripstans include:

This group of drugs usually causes side effects such as dizziness, fatigue, nausea, and rarely, serotonin syndrome or There is over use of medication..

There are slightly different side effects of triptan drugs. The effects vary depending on the person.

Discuss your treatment options with your doctor or pharmacist.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.