If you’re considering treatment options for depression, your doctor might suggest Trintellix (vortioxetine).

Trintellix is a prescription medication that’s used to treat major depressive disorder in adults.

Trintellix is a tablet that you take with your mouth. It is a drug that is in a class of drugs called antidepressants. A class of drugs is a group of drugs that work in the same way.

This article describes the dosages of Trintellix, including its form, strengths, and how to take the drug. To learn more about Trintellix, see this in-depth article.

Note: This article covers Trintellix’s typical dosages, which are provided by the drug’s manufacturer. But when using Trintellix, always take the dosage that your doctor prescribes.

Trintellix is approved to treat major depressive disorder in adults with depression.

What form does Trintellix come in?

Trintellix is a tablet that you take with your mouth.

What are the strengths of Trintellix?

Trintellix tablets are available in three strengths.

Typical dosages of Trintellix (10 mg, 15 mg, or 20 mg)

The information below describes dosages that are commonly used or recommended. However, be sure to take the dosage your doctor prescribes for you. Your doctor will determine the best dosage to fit your needs.

“Trintellix is taken daily with common dosages of 10, 15 and 20. People who don’t like higher doses of Trintellix may need to take a 5-mg dose.”

The normal dosage range for Trintellix is 10 mg to 20 mg per day. Your doctor may increase your dosage to help ease your depression symptoms. If you have side effects from this medication, your doctor may decrease your dosage. For more information about the side effects Trintellix may cause, you can see this in-depth article.

According to the manufacturer’s dosage guide, the typical dosing schedule for Trintellix is once per day, with or without food. You should take the medication around the same time each day.

The lowest dose of Trintellix will be the one your doctor starts you on. They will adjust your medication to reach the right amount. The doctor will prescribe the smallest dose that will provide the desired effect.

Is Trintellix used long term?

Trintellix is a long-term treatment. If you and your doctor agree that Trintellix is safe and effective for you, you will likely use it for a long time.

Dosage adjustments

Certain conditions may affect how your body responds to Trintellix. Your doctor may reduce your dosage if your body is slow to break down an enzyme called CYP2D6.

Some drugs may cause you to have too much or too little Trintellix in your body. Certain medications that affect the CYP2D6 enzyme can interact with Trintellix. To learn more about the drugs that can interact with Trintellix, see this article.

It is important to talk with your doctor about your medication. They can increase or decrease your dose as needed.

Some people have suicidal thoughts or behaviors while taking Trintellix. If you or a loved one taking Trintellix has thoughts of suicide, call your doctor or 911 immediately.

If you experience thoughts of suicide while using Trintellix, your doctor may need to adjust your dose of Trintellix. They may change you to a different treatment.

The amount of Trintellix you are prescribed may be affected by a number of factors. These include:

  • Trintellix can be used to treat a variety of conditions.
  • You are taking other medications.
  • You can see the “Dosage adjustments” section under the “What is Trintellix\’s dosage?” section.

There are a few answers to questions about Trintellix.

Could I be prescribed a Trintellix dosage of 30 mg or 40 mg per day?

It is possible that your doctor may prescribe these dosages.

The maximum amount of medicine most people can take is 20. The dosage may need to be increased for people taking certain medications.

Tell your doctor about all your medication. This helps them prescribe the right Trintellix.

If I’m already taking an antidepressant, what’s the dosage equivalent for Trintellix?

If you’re starting Trintellix, your dosage will depend on the types and dosages of other drugs you’re taking. If you’re already taking an antidepressant drug, your doctor will decide what dosage of Trintellix you should start on.

Will I experience side effects if I miss a dose of Trintellix?

“If you miss one dose of Trintellix, you won’t experience side effects.”

If you suddenly stop taking Trintellix, you may have serious side effects. These include:

If you decide to stop taking Trintellix, you should talk to your doctor about the best way to do it.

The “What if I miss a dose?” section gives tips on remembering to take your dose on time.

“Don’t use more Trintellix than your doctor tells you to. Side effects can be serious if you use more than this.”

Symptoms of overdose

There are symptoms caused by an overdose.

What to do in case you take too much Trintellix

Call your doctor right away if you think you’ve taken too much Trintellix. You can also call 800-222-1222 to reach the American Association of Poison Control Centers, or use their online resource. However, if you have severe symptoms, call 911 (or your local emergency number) immediately or go to the nearest emergency room.

“If you miss a dose, take it as soon as you remember. If you missed your dose, don’t take two more to make up for it. Take the next dose as usual.”

If you have questions about when to take a missed dose, talk to your doctor or pharmacist.

If you need help remembering to take your dose of Trintellix on time, try using a medication reminder. This can include setting an alarm, downloading a reminder app, or setting a timer on your phone. A kitchen timer can work, too.

Trintellix is a tablet that you will take once daily. You can take the tablet with or without food.

Try to take Trintellix at the same time each day. This helps keep the drug in your body in good working order.

Trintellix isn’t known to cause dependence. But you shouldn’t suddenly stop taking Trintellix. Doing so could cause serious side effects, including discontinuation syndrome (antidepressant withdrawal). Symptoms can include:

If you want to stop taking Trintellix, you should talk to your doctor. They will recommend a treatment plan to help you stop taking this drug. Your doctor will gradually reduce your dose until it is safe for you to stop treatment.

“The drug manufacturer’s typical dosages are described in the sections above. If your doctor recommends Trintellix, they will prescribe the correct amount.”

Remember, you shouldn’t change your dosage of Trintellix without your doctor’s approval. Only take Trintellix exactly as prescribed. Talk with your doctor if you have questions or concerns about your current dosage.

Some questions you may want to ask your doctor.

  • Will my dosage need to be lowered if I experience side effects from Trintellix?
  • I’ve been taking Trintellix for a while, but I still have symptoms of depression. Does my dosage need to be adjusted?
  • Can Trintellix interact with other drugs?

For advice about depression and personal stories from others managing this condition, sign up for the Healthline online newsletter and join the Bezzy Depression community.


Trintellix has a suicide warning. Is there any way to tell if a loved one is starting treatment with this drug?



You should talk with your loved one often as they begin taking Trintellix. If you notice that they are having suicidal thoughts or behaviors that could endanger them, contact their doctor immediately.

Suicidal warning signs can be seen.

  • There are threats or comments about self-injury.
  • Increased use of drugs.
  • aggressive, reckless, or impulsive behavior
  • withdrawing from social relationships
  • Dramatic mood changes.
  • Talking, writing, or thinking about death

A prevention hotline can help if you or someone you know is thinking about suicide. The National Suicide Prevention Hotline is open 24 hours a day. People who are hard of hearing can call 800-799-4889 during a crisis.

The Healthline Pharmacist TeamAnswers represent the opinions of our medical experts. All content is strictly informational and should not be considered medical advice.

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.