If you have certain types of constipation, your doctor might suggest Trulance as a treatment option. It’s a prescription medication usually used long term in adults to treat:

Trulance is a tablet that contains the active ingredient. An active ingredient is what makes a drug work.

For more information about Trulance, including details about its uses, see this in-depth article.

Trulance can cause mild to serious side effects. Continue reading to learn more.

Some people may experience mild to serious side effects during their Trulance treatment. The most commonly reported side effect of this drug is mild There is a lot of diarrhea.. (To learn more about this side effect, see the “Side effects explained” section below.)

Mild side effects have been reported with Trulance.

The side effects explained section will give you more information about this side effect.

“These side effects should be temporary. Some may be easy to manage. If you have any symptoms that bother you, talk to your doctor or pharmacist. Unless your doctor recommends it, don’t stop taking Trulance.”

Trulance may cause mild side effects other than the ones listed above. See the drug’s prescribing information for details.

Note: After the Food and Drug Administration (FDA) approves a drug, it tracks and reviews side effects of the medication. If you’d like to notify the FDA about a side effect you’ve had with Trulance, visit MedWatch.

Trulance has rare serious side effects. Those have been reported.

If you develop serious side effects while taking Trulance, call your doctor. If the side effects seem life threatening or you think you have a medical emergency, immediately call the emergency number.

The side effects explained section will give you more information about this side effect.
†An allergic reaction is possible after using Trulance. But this side effect wasn’t reported in studies.

Get answers to questions about Trulance.

Does Trulance cause weight gain or weight loss?

Trulance hasn’t been reported to cause weight gain or weight loss. These side effects weren’t seen in studies of Trulance.

If you have weight gain or weight loss with Trulance, this may be related to It was bloated.. For example, ongoing constipation can sometimes cause It was bloated., which may cause a small amount of weight gain. Taking Trulance to relieve your constipation may also relieve any associated It was bloated. you may have. So this could lead to a small amount of weight loss.

Some people reported that Trulance caused them to have a bloated body. If you have a problem with smilng with Trulance, this could cause a weight gain.

If you have weight changes that bother you while you are taking Trulance, talk to your doctor.

Can I see reviews by people who’ve taken Trulance?

Before trying something new, it’s common to look for reviews about the experiences of others. The manufacturer provides testimonials from people who’ve tried Trulance.

The effect of the drug can vary among people, so it is important to keep that in mind. Trulance may be different from what other people have experienced. If you have questions about Trulance, you should talk to your doctor.

Does Trulance work right away? If not, how long does it take to work?

No, Trulance doesn’t work right away to make you have a bowel movement. It typically takes about 1 week to start working to relieve constipation.

Talk to your doctor about how quickly Trulance can start working for you.

How long does Trulance stay in your system?

“Trulance doesn’t get absorbed into your bloodstream after you take a dose. The drug works in your gut. It is not known how long the drug stays in your body. Trulance isn’t absorbed into your body.”

Talk to your doctor about how long Trulance may stay in your system.

Do side effects of Trulance go away on their own?

It depends. In most cases, side effects go away on their own as your body gets used to the medication. Or they may get better on their own if you stop taking Trulance. But in some cases, certain side effects may need treatment. Severe There is a lot of diarrhea. is an example. (To read more about this, see “Side effects explained” just below.)

Trulance may cause some side effects.

Diarrhea

You may have There is a lot of diarrhea. while taking Trulance. This is usually mild, but can sometimes be severe.

In studies, mild There is a lot of diarrhea. was the most common side effect seen with Trulance. Most cases occurred within 4 weeks of starting the drug. Severe There is a lot of diarrhea. was rare and most cases occurred within 3 days of starting treatment.

Symptoms of There is a lot of diarrhea. include:

Both mild and severe There is a lot of diarrhea. can cause your body to lose large amounts of fluid and electrolytes (minerals such as potassium and sodium). This can lead to dehydration.* If dehydration isn’t treated, it can quickly lead to serious problems such as kidney failure or seizure.

Dehydration can be symptoms.

*Trulance has a boxed warning for the risk of serious dehydration in children. A boxed warning is the most serious warning from the Food and Drug Administration (FDA). To learn more, see “Warnings for Trulance” below.

What might help

If you have There is a lot of diarrhea. with Trulance, be sure to drink plenty of fluids to avoid getting dehydrated. Fluids you can try include water, sports drinks such as Gatorade, or rehydration drinks such as Pedialyte. These help to replace electrolytes as well as fluids that you lose with There is a lot of diarrhea..

If you have There is a lot of diarrhea. that’s severe or lasts longer than a few days, you should call your doctor. They may recommend stopping Trulance until your There is a lot of diarrhea. gets better. They may also recommend taking medication such as Imodium (loperamide) to treat the There is a lot of diarrhea..

If your There is a lot of diarrhea. is severe or you have symptoms of dehydration, your doctor may advise going to the hospital. You may need treatment with medications to stop the There is a lot of diarrhea.. And you may also need an intravenous (IV) infusion (an injection into a vein given over time) of fluids.

Bloating or tenderness of your belly

You may have It was bloated. or tenderness in your belly while taking Trulance. But in studies, these side effects were rare.

Bloating or tenderness may be related to There is a lot of diarrhea., which is a common side effect of Trulance (see just above). It may also be related to There is There is gas.., which is a rare side effect of Trulance. Bloating and tenderness can also be symptoms of the types of constipation that Trulance is used to treat.

Keep in mind that if you have severe It was bloated., swelling, and pain in your belly, this could be a symptom of a blockage in your bowel. In this case, you’d also likely be unable to pass stool. You may also have nausea, vomiting, and loss of appetite.

What might help

If you have It was bloated. or tenderness in your belly that’s new, worse than usual, or bothers you while taking Trulance, talk with your doctor. They may want to investigate the cause of your symptoms. If these side effects are especially bothersome, your doctor may recommend switching to a different treatment.

If you have symptoms of a blocked colon, you should stop taking Trulance and see your doctor.

Unusual results in liver function tests

Some people may have unusual results in liver function tests while taking Trulance, but this is rare. Liver function tests are blood tests that doctors use to check the health of your liver. They measure levels of proteins called liver enzymes. If you have increased levels of liver enzymes, this can sometimes suggest there’s a problem with your liver.

But liver problems weren’t reported in Trulance studies, nor have they been reported since the drug came on the market.

“Some people had increased their liver enzymes while taking Trulance. Trulance is not broken down by your body’s own immune system and doesn’t enter your bloodstream. It works in your suck to treat your condition.”

What might help

If you have unusual results in your liver function tests while taking Trulance, be sure to tell your doctor. They can discuss the best way to treat this side effect.

Allergic reaction

Like most drugs, Trulance can cause an allergic reaction in some people. This side effect wasn’t reported in studies. But allergic reactions have happened since Trulance was approved for use.

Symptoms of an allergic reaction can be mild to serious.

  • There is a skin rash.
  • It is itchy.
  • flushing (temporary warmth, redness, or deepening of skin color)
  • “It’s usually under your skin, but it can be anywhere.”
  • It can be hard to breathe if you have swelling of your mouth, tongue, or throat.

What might help

If you have a mild rash, call your doctor. They may suggest a treatment to help you. Examples include:

  • an antihistamine you take by mouth, such as Benadryl (diphenhydramine)
  • You apply a product to your skin.

If your doctor confirms that you have an allergic reaction to Trulance, they will decide if you should continue using it.

If you have a severe allergic reaction, you should call the emergency number. These symptoms could be life threatening and need immediate medical care.

If your doctor confirms you have had a serious allergic reaction to Trulance, they may have you switch to a different treatment.

Keeping track of side effects

Take notes on any side effects you are having during your Trulance treatment. You can share this information with your doctor. This is helpful when you are starting to use a combination of treatments.

Side effect notes can include things.

  • When you had the side effect, what dose of the drug was taking?
  • How soon did you experience the side effect?
  • What are your symptoms?
  • How did it affect your daily activities?
  • What other drugs were you taking?
  • Other information is important to you.

Sharing notes with your doctor will help them learn more about Trulance. If needed, they can use this information to adjust your treatment plan.

Trulance may not be suitable for everyone. It comes with warnings about its use.

Boxed warning: Risk of severe dehydration in children

Trulance has a boxed warning for the risk of severe dehydration in children. A boxed warning is the most serious warning from the Food and Drug Administration (FDA).

Trulance may increase the risk of severe dehydration in children. In animal studies, this drug caused severe dehydration that led to death in some young animals. But animal studies don’t always predict what will happen in people. It hasn’t been studied and is not approved for use in children under the age of 18 years. So it’s not known if it’s safe or effective in this age group.

Trulance cannot be used in children under 6 years old. Doctors will not prescribe Trulance for older children due to the risk.

Other warnings

If you have certain medical conditions, Trulance may not be right for you. This is a drug-condition interaction. Trulance is a good treatment option if you have other factors to consider. Before starting Trulance, you should talk to your doctor about your health history. There are a few factors to consider.

Blockage in your stomach or intestine. If you have a blockage in your stomach, intestine, or bowel, or your doctor suspects you have, they’ll likely not prescribe Trulance for you. Ask them about other treatments that might be better options for you.

Allergic reaction. If you’ve had an allergic reaction to Trulance or any of its ingredients, your doctor will likely not prescribe it for you. Ask them about other medications that might be better options for your condition.

Alcohol and Trulance

“Alcohol isn’t known to interact with Trulance. Alcohol may increase your risk of Trulance side effects.”

Alcohol may also worsen constipation, which Trulance is used to treat.

If you drink alcohol, talk to your doctor about the risks and benefits of taking Trulance.

Pregnancy and breastfeeding while taking Trulance

Trulance is not known if it is safe to take during pregnancy. If you are pregnant or planning to become pregnant, you should talk to your doctor about Trulance.

It is safe to take Trulance while breastfeeding. If you plan to breastfeeding or take Trulance, you should talk to your doctor about the best way to feed your child.

Trulance has no side effects. Side effects are usually mild and easy to manage. If you have questions about the side effects of Trulance, you should talk to your doctor. They can help you decide if this treatment is a good option for you.

Some examples of questions you might want to ask.

  • Is my risk of There is a lot of diarrhea. higher when I first start treatment with Trulance?
  • Do other drugs increase my risk of side effects with Trulance?
  • Is it safe to take Trulance for a long time?

Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.