Ubrelvy Interactions: Alcohol, Medications, and Others
Ubrelvy (ubrogepant) is a prescription drug that’s used to treat certain kinds of migraine episodes in adults. Like other drugs, Ubrelvy may have interactions.
One substance can cause another substance to have a different effect than expected. Alcohol, another drug, or a supplement can affect how a drug works in your body. If you have certain health conditions, interactions can occur.
Keep reading to learn about Ubrelvy’s possible interactions. And for more information about Ubrelvy, including details about its uses, see this article.
“If you have a health condition, you could be at risk of harm if you take Ubrelvy. Your doctor may not prescribe Ubrelvy for you if that’s the case. This is acontraindication. Thecontraindications of Ubrelvy are listed below.”
If you take certain drugs called strong CYP3A4 inhibitors. When you take a dose of Ubrelvy, certain enzymes (proteins) in your body break down the medication. Specifically, the CYP3A4 enzyme helps break down Ubrelvy after you take a dose.
The medications block the work of the CYP3A4. The medications are called CYP3A4 inhibitors. Some of the medications affect how well they work. This can cause Ubrelvy levels to build up in your body, which can cause side effects. Drugs that act in this way are called strong CYP3A4 inhibitors.
Strong CYP3A4 inhibitors are examples.
- It is a drug called ketoconazole.
- Itraconazole is a drug.
- clarithromycin.
Doctors will not prescribe Ubrelvy with a strong CYP3A4 inhibitor because of the risk. If you need to take Ubrelvy with a weak or moderate CYP3A4 inhibitor, they may adjust your dose. It is important to tell your doctor about all your supplements and medications before you start treatment with Ubrelvy.
If your doctor recommends that you stop using the strong CYP3A4 inhibitor, you should switch to a different treatment. They may prescribe a different treatment for migraines.
If you’ve had an allergic reaction. If you have had an allergic reaction to Ubrelvy or any of its ingredients, your doctor likely won’t prescribe Ubrelvy. You can ask them about other treatments that may be better options for you.
If any of the factors above apply to you, talk to your doctor before you start taking Ubrelvy. Your doctor can tell you if Ubrelvy is safe for you.
There is no known interaction between Ubrelvy and alcohol. Some of the same side effects can be caused by alcohol and ubrelvy. If you combine Ubrelvy and alcohol, you may be at increased risk of having these side effects.
Some people have a migraine episode if they drink alcohol. It is possible that drinking alcohol could make your symptoms worse.
If you drink alcohol, you should talk to your doctor about how much you should drink.
Inform your doctor and pharmacy about any drugs you take before you start taking Ubrelvy. Sharing this information with them may help prevent future interactions.
If you have questions about drug interactions, talk to your doctor or pharmacist.
The drugs that may interact with Ubrelvy are listed in the chart. This chart does not include all drugs that may interact with Ubrelvy. The “Drug interactions explained” section gives more information about some of the interactions.
| Interaction with Ubrelvy | Examples of drugs with this interaction |
| can raise the risk of side effects from Ubrelvy | • It is a drug called ketoconazole. • cyclosporine (Gengraf, others) • clarithromycin. • carvedilol (Coreg) • quinidine • eltrombopag (Promacta) |
| can make Ubrelvy less effective | • rifampin (Rimactane) • phenytoin (Dilantin) |
There are drug interactions that can occur with Ubrelvy.
Interaction with drugs that raise the risk of side effects from Ubrelvy
Taking certain drugs can increase your risk of side effects. For more information, see below.
| What could happen | Examples of drugs with this interaction |
| can increase Ubrelvy levels in your body, which can raise your risk of side effects from Ubrelvy | • It is a drug called ketoconazole. • Itraconazole is a drug. • cyclosporine (Gengraf, others) • fluvoxamine (Luvox) • ciprofloxacin (Cipro) • carvedilol (Coreg) • quinidine • eltrombopag (Promacta) |
What you can do
Inform your doctor and pharmacist of all your medications before you start using Ubrelvy. They will check to see if any of them may cause you problems.
If you’re taking a drug that could interact with Ubrelvy in this way, your doctor will likely lower your Ubrelvy dosage. (To learn more about Ubrelvy’s dosage, see this article.) In some cases, your doctor may prescribe a drug other than Ubrelvy to treat your condition.
Interaction with drugs that can make Ubrelvy less effective
Ubrelvy can be less effective when certain drugs are taken. For more information, see below.
| What could happen | Examples of drugs with this interaction |
| Your body may break down Ubrelvy too quickly. This can decrease Ubrelvy levels in your body, which may make Ubrelvy less effective. | • rifampin (Rimactane) • phenytoin (Dilantin) • carbamazepine (Tegretol, others) |
What you can do
Inform your doctor about all the drugs you take before you start taking Ubrelvy. They can determine if any of them could make Ubrelvy less effective.
If you are taking a drug that could interact with Ubrelvy, your doctor may raise your Ubrelvy dosage. They may prescribe a different drug to treat your condition.
Ubrelvy may have other interactions. They could happen with supplements, foods, vaccines, or even lab tests. See below for more.
Does Ubrelvy interact with supplements?
Before you start taking Ubrelvy, talk with your doctor and pharmacist about any supplements, herbs, and vitamins you take. Sharing this information with them may help you avoid possible interactions.
If you have questions about interactions, talk to your doctor or pharmacist.
Ubrelvy interactions with herbs
The herbal supplements St. John’s wort and curcumin (which is found in turmeric) can interact with Ubrelvy.
“Ubrelvy can be less effective if you take St. John’s wort.”
“Doctors will usually recommend against using St. John’s wort with Ubrelvy because of the risk. They can recommend alternatives to either St. John’s wort or Ubrelvy.”
Taking Ubrelvy with curcumin could raise your risk of side effects from Ubrelvy. Because of this risk, your doctor will likely lower your Ubrelvy dosage if you take it with a curcumin or turmeric supplement. (To learn more about Ubrelvy’s dosage, see this article.)
Ubrelvy and vitamins
There are currently no reports of Ubrelvy interacting with vitamins. But this doesn’t mean that vitamin interactions won’t be recognized in the future.
It is still important to check with your doctor or pharmacist before taking any of these products.
Does Ubrelvy interact with food?
Grapefruit and grapefruit juice may interact with Ubrelvy. Eating grapefruit while taking Ubrelvy may make the drug stay in your body longer. This can increase your risk of side effects from Ubrelvy, such as nausea.
If you consume grapefruit or grapefruit juice, your doctor will likely ask you to avoid these products during your Ubrelvy treatment. Or in some cases, they may lower your Ubrelvy dosage. Your doctor will also likely tell you to avoid taking a second Ubrelvy dose in one day if you’ve consumed grapefruit. (To learn more about Ubrelvy’s dosage, see this article.)
If you have questions about eating grapefruit, talk to your doctor.
Does Ubrelvy interact with vaccines?
Ubrelvy is not known to interact with vaccines.
Does Ubrelvy interact with lab tests?
Ubrelvy is not known to interact with lab tests.
Does Ubrelvy interact with cannabis or CBD?
Ubrelvy can interact with cannabis (marijuana) or cannabis products such as cannabidiol (CBD). Combining Ubrelvy with cannabis can increase the amount of Ubrelvy in your body and raise your risk of side effects. If you use cannabis, talk with your doctor about the risks of using it with Ubrelvy.
Note: Cannabis is illegal at a federal level but is legal in many states to varying degrees.
There is a risk of interactions with Ubrelvy if you have certain medical conditions. Before taking Ubrelvy, you should talk to your doctor. They will determine if Ubrelvy is right for you.
Other factors that might interact with Ubrelvy include:
- Kidney problems. Your kidneys play a key role in removing Ubrelvy from your body after you take a dose. If you have kidney problems, such as chronic kidney disease, Ubrelvy levels could build up in your body. This may raise your risk of side effects, such as sleepiness. If your kidney problems are severe, your doctor will likely prescribe a lower Ubrelvy dosage for you. But if you have end-stage kidney disease, your doctor will likely suggest a treatment other than Ubrelvy for migraine.
- Liver problems. Your liver also plays an important role in getting rid of Ubrelvy after you take a dose. If you have liver problems (such as alcohol-related liver disease), Ubrelvy levels may build up in your body. This could raise your risk of side effects, such as fatigue. If you have a severe liver problem, your doctor will likely prescribe a lower Ubrelvy dosage for you.
- Pregnancy. It’s unknown whether it’s safe to take Ubrelvy while pregnant. If you’re pregnant or planning to become pregnant, talk with your doctor before taking Ubrelvy.
- Breastfeeding. It’s not known if it’s safe to breastfeed while taking Ubrelvy. If you’re currently breastfeeding or planning to breastfeed, talk with your doctor before taking Ubrelvy.
- Allergic reaction. If you’ve had an allergic reaction to Ubrelvy or any of its ingredients, your doctor will likely not prescribe Ubrelvy. You can ask them about other treatments that may be better choices for you.
Taking certain steps can help you avoid getting into arguments with Ubrelvy. Talk to your doctor and pharmacist before treatment begins. Things to discuss with them.
- You can use alcohol or cannabis.
- Other medications you take, as well as any vitamins, supplements, and herbs. Your doctor or pharmacist can help you fill out a
medication list . - If you start taking a new drug, what should you do?
It’s also important to read Ubrelvy’s
Taking Ubrelvy exactly as prescribed can help prevent interactions.
If you still have questions, talk to your doctor.
You may want to ask your doctor some questions.
- Is it possible that I could still take Ubrelvy even if it interacts with a health condition? Is a lower dose safe for me to take?
- Is it safe to take Ubrelvy if I have high blood pressure?
- Do other drugs have the same effects?
- Will my Ubrelvy dose affect my risk of interactions?
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Disclaimer: Healthline has made every effort to make certain that all information is factually correct, comprehensive, and up to date. However, this article should not be used as a substitute for the knowledge and expertise of a licensed healthcare professional. You should always consult your doctor or another healthcare professional before taking any medication. The drug information contained herein is subject to change and is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. The absence of warnings or other information for a given drug does not indicate that the drug or drug combination is safe, effective, or appropriate for all patients or all specific uses.
