“Castleman disease is a rare condition that affects your body’s lymph nodes, causing one or more of them to enlarge. Castleman can cause infections and organ damage if not treated.”

Lymph nodes are small glands located throughout your body, in the armpits, neck, groin, and elsewhere.

Your Lymph nodes are located in your body. White blood cells are stored and used to fight infections.

Some people with Castleman disease have no symptoms at all, while other people have symptoms that are similar to the flu. The exact cause of Castleman disease isn’t known, but having HIV is the largest risk factor for developing the condition.

“Castleman’s treatment depends on how many of the lysies are affected. In this article, we will discuss the types of the disease, possible symptoms, and what treatments are currently available.”

Is Castleman disease cancer?

Castleman disease is not a disease of the body. It is called a lymphoproliferative disorder.

However, according to 2015 research, people with Castleman are at an increased risk of developing certain cancers. Among others, these include:

There are two types of Castleman disease: unicentric and multicentric. Both types affect the lymph nodes, but they vary by the number of lymph nodes involved and the severity of symptoms.

“Let’s break down the characteristics of each.”


Unicentric Castleman disease (UCD) impacts lymph nodes in only one area of the body. It’s also sometimes called localized Castleman disease. Most people with Castleman disease have this type.


Multicentric Castleman disease (MCD) impacts multiple lymph node regions in the body. MCD is more common in people with HIV or who are immunocompromised. People with MCD are more likely to have noticeable symptoms compared with people with UCD.

Castleman disease is not known what the cause is. The underlying causes of Castleman disease are likely different.

Researchers believe that UCD is caused by a genetic mutation, and they are studying multiple different possibilities. A mutation called PDGFRB has been documented in multiple cases of UCD and idiopathic MCD.

MCD is more likely to be developed if you have HIV. People with HIV have a higher chance of getting a specific virus associated with Castleman.

Almost all cases of MCD are linked to an infection with human herpesvirus type 8 (HHV-8), which can cause the cancer Kaposi sarcoma is a type of cancer..

HHV-8 most commonly affects people with HIV or who are immunocompromised. When the disease is not linked to HHV-8, it is called “idiopathic multicentric Castleman disease,” meaning the cause is unknown.

It is important for people with HIV and Castleman to manage their symptoms for the best possible health outcome.

Learn more about HIV treatment.

The symptoms of Castleman disease can be different depending on the type. People with UCD have no symptoms at all.

When UCD does cause symptoms, they can include:

  • It is possible to lose weight unintentionally.
  • There is a high degree of There is a high degree of fever..
  • fatigue
  • A swollen lymph nodes is found in the neck, collarbone, or groin.
  • A feeling of being full in the stomach or chest.
  • Anemia., in some cases, due to a low red blood cell count

MCD causes a lot of symptoms. People with MCD are more likely to have symptoms that prompt them to seek healthcare.

Symptoms of MCD may include:

  • There is a high degree of There is a high degree of fever..
  • The night sweats on.
  • It is possible to lose weight unintentionally.
  • vomiting
  • appetite loss
  • fatigue
  • stomach ache
  • Anemia.
  • Nerve damage.
  • There are swollen lysies in the neck, collarbone, and groin.
  • an enlarged liver or spleen

Since UCD often causes no symptoms, it’s common for UCD to be discovered during routine lab work or testing for another condition. Your doctor might also notice that your lymph nodes are swollen during a physical exam.

The symptoms of MCD can be similar to other conditions. Testing will help rule out other health conditions.

The diagnostic process for Castleman types starts with a physical exam and blood work.

Your doctor might order imaging tests to look for enlarged lymph nodes throughout your body. These tests may include:

If you have swollen lymph nodes, you might have a tissue biopsy done.

A healthcare professional will use a hollow needle to remove a sample of tissue. The sample will be examined under a microscope to confirm a diagnosis.

The treatment for Castleman disease depends on the situation.

  • The type of Castleman disease you have.
  • Which of the lysies are affected?
  • You also have HIV?

Treatment plans can combine several different methods. These include:

  • Surgery. Surgery is often done to remove the affected lymph nodes, but only in UCD. This can prevent or treat UCD’s life threatening complications, mainly organ damage, organ failure, and infection.
  • Radiation treatment. Radiation can be used to shrink tumor (sarcoma) growth. It can be done before surgery to make the removal easier or after surgery to destroy any growth that remains.
  • Immunotherapy. Like There is radiation., immunotherapy can kill tumor cells. In this case, immunotherapy refers to a special antibody medication (rituximab) that’s given to people with multiple myeloma. This treatment attacks and shrinks the abnormal, overactive immune cells. It can generally be used before or after surgery.

Treatments for MCD can include:

  • Chemotherapy. Chemotherapy is used to stop the overgrowth of cancerous cells in the lymphatic system.
  • Corticosteroids. Corticosteroids can help reduce swelling and pain.
  • Antiviral therapy. Antiviral and antiretroviral medications can help get HHV-8 and HIV infections under control. These drugs prevent a virus from multiplying itself, among other effects, making it easier for your immune system to fight it.

Castleman disease causes swollen Lymph nodes. If you have Castleman disease, treatment depends on it.

Some people have no symptoms, while others have life threatening problems. A physical exam and blood work can be used to diagnose Castleman.

It seems that UCD is a result of a genetic abnormality. MCD is usually caused by contracting the HHV-8 virus, and having HIV is a major risk factor.

Treatments for Castleman disease are listed.

  • immunotherapy
  • surgery
  • There is radiation.
  • Therapies.

If you are having swelling or lump under the skin, you should talk to a doctor.

“Scheduling a yearly physical exam is a great way to make sure you don’t have any underlying health conditions, even if you have no symptoms.”

Discuss your risk factors for Castleman disease with your doctor if you have HIV.